(E)-N'-((SUBSTITUTED-3',3'-DIMETHYL-3'H-SPIRO[CHROMENE-2,1'-ISOBENZOFURAN]-8-YL)METHYLENE)ISONICOTINOHYDRAZIDES, HAVING ANTI-TUBERCULOSIS ACTIVITY, AND METHOD THEREOF OBTAINING Russian patent published in 2024 - IPC C07D311/02 C07D315/00 C07D213/56 A61K31/4025 A61P31/06 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds in the series of hydrazones based on isoniazid, specifically to hydrazones of isoniazid and substituted spiropyrans of the oxaindane series (E)-N'-((substituted-3',3'-dimethyl-3'H-spiro[chromene-2,1'-isobenzofuran]-8-yl)methylene)isonicotinohydrazides of general formula:

,

where R' = OH, H; R'' = H, CH_3, t-Bu, OCH₃, in particular, provided 1a) R' = OH; R'' = H; 1b) R' = H; R'' = CH₃; 1c) R' = H; R'' = t-Bu; 1d) R' = H; R'' = OCH₃, as well as to a method for their production, and can be used in the development of anti-tuberculosis drugs.

EFFECT: novel compounds of formula 1 are obtained, having a new property of anti-tuberculosis activity comparable to activity of hydrazones based on isoniazid used as medicinal agents.

8 cl, 1 dwg, 2 tbl, 4 ex