FIELD: chemistry.
SUBSTANCE: invention relates to a conjugate of an anti-TROP-2 antibody and an exatecan analogue and its medical use. Presented is a conjugate of an anti-TROP-2 antibody and an exatecan analogue of general formula (Pc-L-Y-D), where Pc is an anti-TROP-2 antibody or an antigen-binding fragment thereof.
EFFECT: greater tumor efficacy.
35 cl, 5 dwg, 9 tbl, 3 ex
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