FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing compound 6-chloro-2-ethyl-N-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide ditosylate, having the following peaks in the X-ray powder diffractometry (XRPD) spectrum obtained by irradiating with Cu-Kα radiation (Cu-Kα): 3.9°2θ, 5.6°2θ, 8.0°2θ, 16.1°2θ, 19.1°2θ and 22.4°2θ, ± 0.2°2θ. Method of obtaining is carried out by providing in any order free base 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide and para-toluenesulphonic acid in a stoichiometric ratio of 1:2; mixing and dissolving them in a suitable solvent, where the solvent is isopropyl alcohol (IPA), or in a mixture of solvents, which is a mixture of tetrahydrofuran (THF) and acetone; and evaporating the solvent or mixture of solvents.
EFFECT: obtaining 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide ditosylate in a stable form.
3 cl, 78 dwg, 27 tbl, 3 ex
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