METHOD FOR PRODUCING N-(5-(3-(7-(3-FLUOROPHENYL)-3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-INDAZOL-5-YL)PYRIDIN-3-YL) -3-METHYL BUTANAMIDE Russian patent published in 2022 - IPC C07D471/04 

FIELD: organic chemistry.

SUDSTANCE: the invention relates to the field of organic chemistry, namely to a method for obtaining a compound of formula (1) or its salt, including (a) the interaction of the compound of formula (8) or its salt with bis(pinacolato)diborone and Pd(dppf)Cl2 to obtain a compound of formula (9) or its salts; (b) reacting a compound of formula (9) or a salt thereof with a compound of formula (10) or a salt thereof with Pd(PPh3)4 and K3PO4 to give a compound of formula (11) or a salt thereof; (c) reacting a compound of formula (11) or a salt thereof with a compound of formula (6) or a salt thereof to give a compound of formula (12) or a salt thereof; and (d) deprotecting a compound of formula (12) or a salt thereof to give a compound of formula (1) or a salt thereof, wherein deprotection of a compound of formula (12) to give a compound of formula (1) comprises reacting a compound of formula (12) with pure TFA.

EFFECT: a new method for obtaining a highly pure compound of formula (1) useful in the treatment of diseases associated with Wnt has been developed.

46 cl, 58 dwg, 33 tbl, 5 ex