METHODS OF TREATING DISEASES AND DISORDERS ASSOCIATED WITH LSD1, LSD1 INHIBITORS Russian patent published in 2024 - IPC A61K31/40 A61P35/02 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to treatment of tumours associated with LSD1, or acute myeloid leukaemia. Disclosed are methods of treating a malignant tumour associated with LSD1 in a patient in need thereof, comprising administering effective amount 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]phenyl]-2-fluorobenzonitrile or a pharmaceutically acceptable salt thereof to a patient according to an administration schedule providing for daily administration for one or two weeks, followed by a rest period of one week. Also disclosed are methods of treating acute myeloid leukaemia (AML) in a patient in need thereof, comprising administering effective amount 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]phenyl]-2-fluorobenzonitrile or a pharmaceutically acceptable salt thereof to a patient as a single agent administered once day for 28-day cycle, providing the introduction for one week, followed by a rest period of one week, or 21-day cycle, providing for the introduction daily for two weeks, followed by a rest period of one week.

EFFECT: group of inventions provides preservation of clinical effectiveness with reduction of side effects of treatment due to recovery of thrombocyte and neutrophil count during a break in taking drug of 1 week.

10 cl, 6 dwg, 2 tbl, 3 ex