SOLID DISPERSIONS AND PHARMACEUTICAL COMPOSITIONS INCLUDING SUBSTITUTED INDANE, AND METHODS FOR PRODUCTION AND APPLICATION THEREOF Russian patent published in 2022 - IPC A61K31/10 A61K31/275 A61K9/10 A61K9/20 A61K9/48 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to an HIF-2α-inhibiting pharmaceutical solid dosage form for oral administration of a compound by the formula (I)

Formula (I),

and to methods for treatment including administration of said dosage form. The solid dosage form includes a solid dispersion including a compound by the formula (I) and one or more pharmaceutically acceptable excipients. The solid dispersion therein includes a pharmaceutically acceptable polymer selected from the group consisting of hydroxypropyl methylcellulose acetate (HPMCAS), cellulose acetate phthalate (CAP), and a polyethylene glycol-polyvinyl acetate-polyvinyl caprolactam graft copolymer, and the solid dosage form constitutes a capsule or tablet. Also claimed is a method for treating von Hippel-Lindau disease (VHL) and a method for treating renal cell carcinoma.

EFFECT: invention increases the stability, bioavailability, and quality of storage of the pharmaceutical dosage form.

18 cl, 15 dwg, 33 tbl, 18 ex