TREATMENT OF HYPOPARATHYROIDISM Russian patent published in 2024 - IPC A61K38/29 A61P5/18 

FIELD: medicine.

SUBSTANCE: invention relates to treatment of hypoparathyroidism. Disclosed is the use of a PTH compound for the treatment of hypoparathyroidism, treatment includes single daily administrations of the compound to a human patient and avoiding the use of standard therapy for four weeks from the moment of administration of the first dose of the compound, compound PTH is a compound of formula (IIf-i):

where the unmarked dotted line shows the attachment to the N-terminal amine functional group of the PTH fragment having the sequence SEQ ID NO: 51; dotted line marked with an asterisk shows attachment to fragment

,

where m and p are independently integer of 400–500, where the single daily dose is selected from 15 mcg/day, 18 mcg/day, 21 mcg/day, the daily dose of the compound can be adjusted depending on the serum calcium level.

EFFECT: invention provides treating hypoparathyroidism with reduced side effects.

9 cl, 2 tbl, 3 ex