MULTIVALENT IMMUNOTHERAPEUTIC COMBINATION AND METHODS OF USE FOR TREATING WT1-POSITIVE CANCERS Russian patent published in 2024 - IPC A61K39/39 A61K35/00 A61K45/06 A61P37/04 

FIELD: biotechnology.

SUBSTANCE: there are presented: an immunotherapeutic composition for treating WT1 expressing cancer, reducing the incidence of WT1 expressing cancer or inducing immune responses against WT1 expressing cancer, containing: a) a combination of at least seven isolated peptides, (b) one or more nucleic acid molecules coding a combination of at least seven isolated peptides from (a); or (c) an immune cell containing one or more nucleic acid molecules according to (b), coding a combination of at least seven peptides from (a), and/or containing or presenting at least seven peptides from (a); or (d) cytotoxic T cells (CTL) against WT1 expressing cancer, induced by a combination of at least seven isolated peptides from (a); or (e) a combination of two, three or all four of (a), (b), (c) and (d). Also disclosed are methods of treating cancer, reducing the incidence of cancer, inducing an immune response against cancer expressing WT1, inducing formation and proliferation of T-cells specific for cancer.

EFFECT: invention can be used to treat cancer in a subject in need thereof.

51 cl, 2 tbl, 1 ex