SET OF RECOMBINANT GENETIC VECTORS CODING BROADLY NEUTRALIZING ANTIBODIES AGAINST HIV-1, IMMUNOBIOLOGICAL PREPARATION FOR TREATMENT AND PREVENTION OF HIV INFECTION AND METHOD OF ITS APPLICATION Russian patent published in 2025 - IPC A61K35/761 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, namely to recombinant genetic vectors based on adeno-associated virus, coding broadly neutralizing antibodies against human immunodeficiency virus (HIV-1), as well as to immunobiological preparations based on them for treating and preventing HIV infection by providing long-term persistence of widely neutralizing antibodies against HIV-1. Described is a set of recombinant genetic vectors coding broadly neutralizing antibodies against HIV-1, directed to different epitopes of viral protein Env, where the recombinant genetic vector used is an adeno-associated vector of serotype 9. What is presented is an immunobiological preparation for treating or preventing HIV-1 infection, containing a combination of several serotype 9 adeno-associated vectors selected from a set. Also disclosed is a method of using an immunobiological preparation, characterized by the fact that the preparation is administered intramuscularly in the form of a mixture of adeno-associated vectors of serotype 9 or each adeno-associated vector of serotype 9, which is part of the combination, is administered separately.

EFFECT: creation of an immunobiological preparation for treating and preventing HIV infection based on various combinations of recombinant genetic vectors based on adeno-associated virus serotype 9 expressing broadly neutralizing anti-HIV-1 antibodies.

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