FIELD: biotechnology.
SUBSTANCE: disclosed is a method for assessing the efficacy of an in vitro composition for reducing the effect of an anticancer therapeutic agent on the skin, comprising using a three-dimensional model of the epidermis in vitro or ex vivo, showing differentiating keratinocytes in the reconstructed stratum corneum; wherein said model comprises an anti-cancer therapeutic agent in an amount effective to simulate prolonged drug exposure; wherein the anticancer therapeutic agent is afatinib, and the skin barrier function is assessed by measuring transepidermal water loss (TEWL) rates in said model.
EFFECT: method can be used to assess the ability of anticancer therapeutic agents to cause skin-related side effects.
2 cl, 7 dwg, 3 tbl
| Title |
Year |
Author |
Number |
| METHOD FOR IMPROVING SKIN CELL DIFFERENTIATION |
2010 |
- Dzhejkobson Ehlejn L.
- Dzhejkobson Majron K.
- Kojl Rassel
- Kim Kh'Junte
- Kojl Donna L.
|
RU2463046C2 |
| MEANS OF REDUCING THE SIDE EFFECTS CAUSED BY RETINOIC ACID |
2008 |
- Dzhejkobson Ehlejn L.
- Dzhejkobson Majron K.
- Kojl Rassel
- Kim Kh'Junte
- Kojl Donna L.
|
RU2442577C2 |
| METHOD FOR SELECTING MODES, INGREDIENTS AND COMPOSITIONS FOR TREATING SKIN |
2020 |
- Kapone, Kimberli
- Nikolovski, Dzhaneta
- Telofski, Lorena
- Stamata, Zhorzhio
|
RU2816982C2 |
| USE OF PLANT EXTRACT AS ACTIVE AGENT IN TREATMENT OF DERMATOLOGICAL DISEASES |
2018 |
- Alimonti, Andrea
- Dzhori, Andrea Mariya
- Montopoli, Monika
- Kadau, Dzhessika
|
RU2782197C2 |
| METHOD FOR SELECTING SKIN BARRIER SYSTEM ACCEPTABLE FOR INFANTS AND YOUNG CHILDREN |
2020 |
- Bensaki, Dzhalil
- Oddo, Terri
- Stamatas, Georgius N.
- Greni, Eleya
|
RU2819154C2 |
| CELLULAR LINE OF IMMORTALIZED KERATINOCYTES AND MELANOCYTES (VARIANTS), METHOD FOR IMMORTALIZATION OF HUMAN SKIN CELLS FOR PREPARING IMMORTALIZED KERATINOCYTES, METHOD FOR IMMORTALIZATION OF HUMAN SKIN CELLS FOR PREPARING IMMORTALIZED MELANOCYTES, SERUM-FREE MEDIUM (VARIANTS), ANALYSIS OF CUTANEOUS RESPONSES |
1996 |
- Baur Markus
- Mas Katrin
- Malne Arman
- Pfajfer Andrea M. A.
- Ren'E Marsel'
|
RU2215030C2 |
| PREPARATIONS, CONTAINING ANTIBODIES AGAINST Fas LIGAND, FOR TREATING PEMPHIGUS |
2009 |
- Pinchelli, Karlo
- Markoni, Alessandra
|
RU2556818C2 |
| COMPOSITION CONTAINING LIPID NANOPARTICLES AND CORTICOSTEROID OR VITAMIN D DERIVATIVE |
2012 |
- Jensen Luize Bastkholm
- Petersson Karsten
|
RU2602171C2 |
| METHOD OF PRODUCTION OF BIOMASS CONTAINING PLANTARICYNE AND ITS USE FOR MEDICAL PURPOSES |
2011 |
- Dzhuliani Dzhammarija
- Beneduzi Anna
- Gobetti Marko
- Dl' Kan'O Raffaehlla
- De Andzhelis Marija
- Kalasso Marija
|
RU2566999C2 |
| COMPOSITIONS CONTAINING AMPELOPSIS GROSSEDENTATA EXTRACTS AND ALBIZIA JULIBRISSIN EXTRACTS, AND METHODS OF USING THEM |
2016 |
- Du, Hua
- Li, Yan
- Liu, Tao
- Ma, Yingxin
|
RU2731561C2 |
