FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, to novel biologically active substances of the class of substituted pyridazine-3(2H)-ones. Disclosed is 4-bromo-N'-((2-((2-(4-bromobenzoyl)-3-oxo-6-phenyl-2,3-dihydropyridazin-4-yl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(imino)methyl)benzohydrazide of formula 1.
EFFECT: obtaining a compound of formula 1 with high output, having pronounced analgesic activity, as well as low toxicity.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| N'-(IMINO(2-((6-(2-METHOXYPHENYL)-2-(4-NITROBENZOYL)-3-OXO-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-3-YL)METHYL)-4-NITROBENZOHYDRAZIDE, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrij Vladimirovich
|
RU2831250C1 |
| OBTAINING 2-((6-(2-METHOXYPHENYL)-3-OXO-2-ETHYL-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBONITRILE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
RU2808995C1 |
| 5-PHENYL-2-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)IMINO-2H-FURAN-3-ONE, POSSESSING ANTIMICROBIAL AND ANALGETIC ACTIVITY |
2014 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
- Panchenko Aleksej Olegovich
- Balandina Svetlana Jur'Evna
|
RU2560521C1 |
| N-ETHYL-2-((3-OXO-6-(4-FLUOROPHENYL)-2-ETHYL-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXIMIDE HYDRAZIDE, HAVING ANTIMICROBIAL ACTIVITY |
2024 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
RU2831253C1 |
| 4-(4-METHOXYPHENYL)-4-OXO-N-PHENYL-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
|
RU2810072C1 |
| 2-((6-(4-BROMOPHENYL)-3-OXO-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBONITRILE, HAVING ANTIMICROBIAL ACTIVITY WITH RESPECT TO CANDIDA ALBICANS |
2024 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
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| 4-(3,4-DIMETHOXYPHENYL)-2-[2-(4-METHYLBENZOYL)HYDRAZONO]-4-OXO-N-[4-(N-THIAZOL-2-YL)SULFAMOYL)PHENYL]BUTANAMIDE, HAVING ANALGESIC ACTIVITY |
2024 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
|
RU2829965C1 |
| (Z)-2-[(3-CARBAMOYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMINO]-4-(4-R-PHENYL)-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
|
RU2503671C1 |
| 1,6-DIOXO-1-METHOXY-6-PHENYL-2-CYANO-4-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)HEXA-2,4-DIENE-3-OLATE OF POTASSIUM, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrij Vladimirovich
|
RU2829961C1 |
| 4-OXO-N-(FURAN-2-YLMETHYL)-4-(4-CHLOROPHENYL)-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Okoneshnikova Elizaveta Aleksandrovna
|
RU2798425C1 |
