SULFONAMIDE OR SULFINAMIDE COMPOUND HAVING EFFECT OF INDUCING DEGRADATION OF BRD4 PROTEIN, AND ITS USE IN MEDICINE Russian patent published in 2024 - IPC C07D495/14 C07D487/04 A61K31/5517 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a sulfonamide or sulfinamide compound or a pharmaceutically acceptable salt thereof, which has an effect inducing BRD4 protein degradation in cancer cells, and to its use as an anticancer drug. Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof, where A and Q each independently represent a ring selected from phenyl; 5–6-membered aromatic heterocycle containing 1 nitrogen atom; ring is optionally substituted with a group selected from a halogen atom and a cyano group; Z¹ is C, Z² is C, Z³ is a group =CR^Z3-, Z⁴ is a group =CR^Z4-, Z⁵ is a group =CR^Z5-, R^Z3, R^Z4, and R^Z5 each independently represents a group selected from a hydrogen atom; halogen atom; hydroxyl group; cyano group; a C_1–6alkyl group optionally substituted with a group selected from a halogen atom, a hydroxyl group, and C_1–6alkoxy group; C_3–10cycloalkyl group; and C_1–6alkoxy group; substructures , are presented in the claim of the present invention. L, T and M are presented in the formula of the present invention, G is N, J is N, n is 1 or 2; R⁵ is a hydrogen atom; R^6a and R^6b each independently represent a group selected from a hydrogen atom, a halogen atom; and a cyano group; R^7a and R^7b each independently represent a hydrogen atom or a C_1–6alkyl group optionally substituted with a hydroxyl group, or R^7c represents a hydrogen atom, R^7r is a C_2–6alkylene group, R^8a and R^8b each independently represent a group selected from a hydrogen atom, a halogen atom; and C_1–6alkoxy group; R^9a and R^9b each independently represent a group selected from a hydrogen atom; a C_1–6alkyl group, optionally substituted with a hydroxyl group, and C_1–6alkoxy group; R^10a and R^10b each independently represent a substitute selected from a hydrogen atom, and a C_1–6alkyl group, optionally substituted with a substitute selected from a cyano group; C_1–6alkoxycarbonyl group; hydroxycarbonyl group and -CO-N(R^7a)(R^7b); and R¹¹ is a C_1–6alkyl group. Invention also relates to individual compounds, as well as a pharmaceutical composition based on said compounds and use thereof for treating cancer by BRD4 protein degradation.

EFFECT: obtaining alternative compounds inducing BRD4 protein degradation, which can be used in medicine as an anticancer drug.

24 cl, 2 dwg, 8 tbl, 150 ex