TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS Russian patent published in 2017 - IPC C07D471/14 C07D487/14 C07D498/14 C07D513/14 A61K31/4375 A61K31/519 A61K31/5365 A61K31/542 A61P19/02 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by the formula : , where the A^a ring is represented by the following formula , where T^1a is a nitrogen atom, U^1a is a nitrogen atom, X^a is CR^9a (where R^9a represents a hydrogen atom), Y^a a is CR^10a (where R^10a is a hydrogen atom), R^1a is a hydrogen atom, ring B^a is C_4-7cycloalkane, benzene or a 4 to 6-membered non-aromatic heterocycle containing 1 heteroatom selected from a nitrogen atom, L^1a is a single bond, L^2a is a single bond, C_1-3 is an alkylene group (C_1-3 alkylene group is unsubstituted or substituted by a cyano group) or C_1-3 halogenoalkylene group, L3a is a single bond or is represented by any of the following formulas: n^a is 0 or 1, R^3a is a hydroxy group, a halogen atom, a cyano group or a methyl group, the remaining radicals are as defined in the claims. The invention also relates to a compound represented by the formula (I^b), to a JAK inhibitor containing the compound of the invention, to a preventive, therapeutic or improving agent for diseases in which JAK inhibition is effective, to a drug.

EFFECT: new compounds with inhibitory activity against JAK are obtained.

36 cl, 236 tbl, 611 ex