FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to nicotinamide derivatives of formula (I) exhibiting the property of Syk-kinase inhibitor and to a based pharmaceutical composition. In general formula
R1 means halogen atom; R2 means a substitute presented by formula as follows
and R3 means a pyridyl group presented by formulas as follows (VIII-1) or (VIII-2); R4 and R5 mean hydrogen atom. The other radicals are presented in the patent claim.
EFFECT: producing new nicotinamide derivatives.
13 cl, 2 dwg, 25 tbl, 47 ex
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