COMBINED NANOPARTICLES BASED ON AMPHIPHILIC COPOLYMERS OF N-VINYLPYRROLIDONE FOR COMBINED TARGETED DRUG DELIVERY Russian patent published in 2024 - IPC A61K9/14 A61K31/4965 A61K31/69 A61K38/19 A61K47/50 A61K47/69 A61P35/00 B82B1/00 B82Y5/00 

FIELD: chemistry; biotechnology; pharmaceutics.

SUBSTANCE: invention relates to chemistry, biotechnology and pharmaceutics, specifically to a nanoparticle for delivering anticancer drugs. Disclosed nanoparticle is a micelle consisting of amphiphilic polymers with number-average molecular weight of 1–30 kDa of general formula C₄H₂NO₂-(--M--)-(CO)-R and Cl-(--M--)-(CO)-R, where (--M--) is hydrophilic part of N-vinylpyrrolidone monomers, and R is a hydrophobic part with the structure -(C_8-19-alkyl)-CH₃, wherein one of the anticancer drugs is low-molecular and is located in the nucleus of the nanoparticle, and the other anti-tumour preparation is conjugated with the surface of the nanoparticle and is a target receptor-specific substance of a peptide nature, which is a variant of the cytokine TRAIL, selected from DR5-B with an amino acid sequence homologous to at least 90% of the sequence SEQ ID NO: 1, and DR5-B-iRGD with an amino acid sequence homologous to at least 90% of the sequence SEQ ID NO: 2.

EFFECT: invention provides novel combined micellar nanoparticles characterized by improved pharmacokinetic properties, enhanced therapeutic effect and controlled release of the preparation from the hydrophobic core.

7 cl, 5 dwg, 7 ex