FIELD: biotechnology.
SUBSTANCE: disclosed is an antigen-binding protein (ABP) capable of binding to human fms-like tyrosine kinase 3 (FLT3), wherein ABP is an antibody or an antigen-binding fragment thereof, comprising: a heavy chain variable region comprising an amino acid sequence selected from SEQ ID NO: 15, 17, 19, 21, 23 or 76, and a light chain variable region containing an amino acid sequence selected from SEQ ID NO: 16, 18, 20, 22, 24 or 77. Also disclosed are: a pharmaceutical composition for preventing or treating a proliferative disease, a method for enhancing a cell-mediated immune response to a human cell which expresses human FLT3, and a method of treating a proliferative disorder in a subject, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition.
EFFECT: invention is used to treat proliferative disorders associated with FLT3 expression, where the disorder is cancer, in particular, such as leukemia, solid cancer, prostate cancer, colorectal cancer, stomach cancer, lung carcinoma, osteosarcoma, breast cancer, pancreatic cancer or squamous cell carcinoma.
22 cl, 11 dwg, 2 tbl, 7 ex
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