N-(PHENYLSULPHONYL) BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS Russian patent published in 2024 - IPC C07D471/00 A61K31/444 A61K31/4545 A61K31/496 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula II and formula VII, and pharmaceutically acceptable salts thereof. In formula II: Y is -O-; R² is -NO₂; R^4a is selected from a group consisting of unsubstituted C1-6 alkyl and (heterocyclo)alkyl. In formula VII: Y is selected from a group consisting of -CH₂- and -O-; X¹, X², and X³ each independently represents -CR⁸=; R² is -NO₂; R^4a is selected from the group consisting of unsubstituted C1-6 alkyl and (heterocyclo)alkyl; and R⁸ is hydrogen. (Heterocyclo)alkyl is C1-4 alkyl substituted with one heterocyclyl group, where the heterocyclyl group is 6-member cyclic group containing one ring and one or two oxygen atoms.

EFFECT: disclosed compounds inhibit Bcl-2 proteins and are used in treating a disease, disorder or condition susceptible to Bcl-2 protein inhibition, such as cancer.

4 cl, 4 dwg, 7 tbl, 20 ex