APOPTOSIS INDUCING AGENTS FOR TREATING MALIGNANT NEW GROWTH, AND IMMUNE AND AUTOIMMUNE DISEASES Russian patent published in 2014 - IPC C07D471/04 A61K31/437 A61K31/496 A61K31/5377 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula

wherein A¹ represents N or C (A²); A² represents H, F, Cl or CN; B¹ represents H, OR¹, SO₂R¹, NHR¹, NHC(O)R¹, F or Cl; D¹ and E¹ represents H or Cl; Y¹ represents H, CN, NO₂, F, Cl, Br, CF₃, R¹⁷, OR¹⁷, SO₂R¹⁷ or C(O)NH₂; or Y¹ and B¹ together with atoms to which they are attached, represent 5- or 6-merous heteroarene having 2-3 nitrogen atoms, wherein heteroarene rings are unsubstituted or substituted by (O); G¹ represents H; Z¹ represents uncondensed phenylene substituted by OR⁴¹; R⁴¹ represents 6-merous heteroaryl having 1 N atom, wherein heteroaryl is condensed with R^43A, R^43A represents 5-merous heteroarene having 1 N atom; Z² represents monocyclic 6-merous heterocycloalkylene having 1-2 N atoms and 0 double bonds; Z^1A and Z^2A are both absent; L¹ represents -CH₂-; Z³ represents R³⁸ or R⁴⁰; R³⁸ represents uncondensed phenyl; R⁴⁰ represents cycloalkyl, wherein cycloalkyl represents a monocyclic ring system having 3 to10 C atoms and 0 double bonds, cycloalkenyl, wherein cycloalkenyl represents monocyclic 6-merous ring having 1 heteroatom specified in a group consisting of O and N, and 1 double bond, wherein cycloalkenyl is uncondensed or condensed with R^40A; R^40A represents cycloalkane, wherein cycloalkane represents a monocyclic ring having 3-10 C atoms and 0 double bonds, or heterocycloalkane, wherein heterocycloalkane represents monocyclic 6-merous ring having 1 N atom and 0 double bonds (the rest substitutes are those as specified in cl. 1 of the patent claim). The invention also refers to compounds of formula

and a pharmaceutical composition containing an effective amount of the compound of formula (I) or (II) or its pharmaceutically acceptable salt.

EFFECT: compounds of formula (I) or (II) inhibiting the activity of anti-apoptotic Bcl-2 proteins.

6 cl, 5 tbl, 378 ex