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2 573 832

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IPC

C07D471/04(2006-01-01)

A61K31/496(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014132884/04, 2010-05-26

(24)

Start date

2010-05-26

(22)

Actual filing date

2010-05-26

(45)

Published

2016-01-27

(72)

Inventor

Branko MilanDin KhunDouehrti DzhordzhEhlmor StivenKhasvol'D LizaKheksamer LauraKanzer Aaron R.Sun SjaokhunSauehrs Ehndrju Dzh.Sallivan DzherardTao Chzhi-FuVan Gari T.Van LehVan SiluUehndt MajklMantej RobertKhansen Todd M.

(73)

Holder

Ehbbvi Bakhamaz Ltd.

APOPTOSIS-INDUCING AGENTS FOR TREATING MALIGNANT TUMOURS AND IMMUNE AND AUTOIMMUNE DISEASES Russian patent published in 2016 - IPC C07D471/04 A61K31/496 A61P35/00

Abstract RU 2573832 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulphonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide and a pharmaceutical composition containing a therapeutically effective amount of said compound. As a result, 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulphonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide is obtained, which inhibits anti-apoptotic protein Blc2 activity.

EFFECT: high activity.

2 cl, 5 tbl, 378 ex

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RU 2 573 832 C2

Authors

Branko Milan

Din Khun

Douehrti Dzhordzh

Ehlmor Stiven

Khasvol'D Liza

Kheksamer Laura

Kanzer Aaron R.

Sun Sjaokhun

Sauehrs Ehndrju Dzh.

Sallivan Dzherard

Tao Chzhi-Fu

Van Gari T.

Van Leh

Van Silu

Uehndt Majkl

Mantej Robert

Khansen Todd M.

Dates

2016-01-27—Published

2010-05-26—Filed