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2 831 205

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IPC

C12Q1/00(2006-01-01)

C12Q1/68(2006-01-01)

C12Q1/6876(2018-01-01)

(21) (22)

Application

2024118691, 2024-07-04

(24)

Start date

2024-07-04

(22)

Actual filing date

2024-07-04

(45)

Published

2024-12-02

(72)

Inventor

Azarova Iuliia EduardovnaPostnikova Mariia IgorevnaKlesova Elena IurevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR GENOTYPING SINGLE-NUCLEOTIDE VARIANT rs2269578 (G>C) OF HUMAN XBP1 GENE BY REAL-TIME POLYMERASE CHAIN REACTION Russian patent published in 2024 - IPC C12Q1/00 C12Q1/68 C12Q1/6876

Abstract RU 2831205 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, molecular genetic diagnostics. Disclosed is a method for genotyping a single nucleotide variant rs2269578 (G>C) of the human XBP1 gene by real-time polymerase chain reaction. Disclosed method is carried out using primers XBP1-F 5'-CCATCCGGAGTGACAGAATT-3', XBP1-R 5'-GGCGCACGAGATAAAATGTTG-3' and probes XBP1-G-allele-specific fluorescent-labelled probe 5'-FAM-AATTTAATTCCAAACCG-RTQ1-3', XBP1-C-allele-specific fluorescent-labelled probe 5'-ROX-AATTTAATTCCAAACCC-BHQ-3'.

EFFECT: invention allows to simplify human genotyping by alleles rs2269578-G and rs2269578-C of the XBP1 gene, to reduce analysis time.

1 cl, 2 dwg, 3 ex

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RU 2 831 205 C1

Authors

Azarova Iuliia Eduardovna

Postnikova Mariia Igorevna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2024-12-02—Published

2024-07-04—Filed