METHOD OF PRODUCING DESFLURANE Russian patent published in 2025 - IPC C07C41/18 C07C43/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing desflurane – a fluorine-organic inhalation anaesthetic of the latest generation, which is widely used in surgical practice, due to high efficacy and low blood solubility, which promotes more rapid elimination and minimization of negative processes for the body. Disclosed method involves a step for condensation of fluoroanhydride compounds of general formula R-COF, where R=CCl₃, CF₂J, COF, with hexafluoropropylene oxide in molar ratio equal to 1:(0.36-0.60), in the presence of an alkali metal fluoride and a polar aprotic solvent to form condensation products of general formula R-CF₂OCF(CF₃)COF, where R has the above values. Further, the condensation products of general formula R-CF₂OCF(CF₃)COF, where R=CCl₃, CF₂J, with oleum at temperature of 60-70 °C for 24 hours and separation of formed dihalogenohydrides by washing with 100% sulphuric acid and fractionation. Obtained dihalogen anhydrides of general formula R'-CF₂OCF(CF₃)COF, where R'=COCl, COF, reacting with low-molecular alcohols at temperature of 5-30 °C. Formed dialkyl-perfluoro-2-methyl-3-oxapentanedioate is saponified with alkalis in a high-temperature solvent to obtain perfluoro-2-methyl-3-oxapentanedioate, which is subjected to thermal decarboxylation at temperature of 135-185 °C, with simultaneous distillation of formed desflurane.

EFFECT: creation of a method which is more manufacturable on an industrial scale, which excludes the use of hydrogen fluoride and non-standard process equipment when carrying out all synthesis and purification steps with high output and selectivity.

10 cl, 8 ex