METHODS OF COMBINED TREATMENT OF MALIGNANT NEOPLASMS, INCLUDING AGENTS BLOCKING CTLA-4 AND PD-1 Russian patent published in 2025 - IPC A61K39/395 C07K16/28 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to medicine and pharmaceutics, namely to a method of treating a malignant neoplasm in an individual in need of such treatment, using a combination of antibodies against PD-1 and an anti-CTLA-4 antibody which does not cause moderate to severe inflammatory immune-mediated skin or intestinal toxicity, wherein said method involves administering a combination of a heavy chain (HC) anti-PD-1 antibody containing the amino acid sequence presented in SEQ ID NO: 27, and a light chain (LC) containing the amino acid sequence presented in SEQ ID NO: 28, and an anti-CTLA-4 antibody containing (i) HC, having a variable domain HC (VH) containing the amino acid sequence presented in SEQ ID NO: 7, and an HC constant domain containing the amino acid sequence presented in SEQ ID NO: 38, 39, 40, 41, 42, 43 or 44, and (ii) LC having a variable domain LC (VL) containing the amino acid sequence presented in SEQ ID NO: 8, and a constant LC domain containing the amino acid sequence presented in SEQ ID NO: 57.

EFFECT: anticancer activity of the anti-CTLA-4 antibody when administered together with the anti-PD-1 antibody without immune-mediated skin and intestinal toxicity.

6 cl, 11 dwg, 36 tbl, 3 ex