LIQUID FORMULATIONS OF PROTEINS CONTAINING VISCOSITY-LOWERING AGENTS Russian patent published in 2025 - IPC A61K9/08 A61K39/395 A61K47/12 A61K47/20 A61G3/00 C07K1/14 

FIELD: biotechnology.

SUBSTANCE: invention relates to low-viscosity protein compositions. Method of reducing the viscosity of a formulation comprising an antibody comprises a step of combining the antibody, a pharmaceutically acceptable solvent and thiamine or a pharmaceutically acceptable salt thereof, where the formulation contains at least 100 mg/ml of the antibody, from 0.10 M to 0.25 M of thiamine or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvent, where the absolute viscosity of the formulation is less than the absolute viscosity of the control formulation containing the antibody and a pharmaceutically acceptable solvent, but without thiamine or a pharmaceutically acceptable salt thereof.

EFFECT: invention provides concentrated low-volume liquid pharmaceutical formulations of proteins with low viscosity.

14 cl, 9 dwg, 40 tbl, 28 ex