BIODEGRADABLE DRUG DELIVERY SYSTEMS FOR LONG-TERM RELEASE OF PROTEIN Russian patent published in 2018 - IPC A61K47/50 A61K47/68 A61K9/00 A61K38/00 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to biodegradable implants with a long-term release of protein into the tissue of mammals. Extruded biodegradable intraocular implant is disclosed that contains a biodegradable polymer matrix and protein associated with the biodegradable polymer matrix, moreover, the biodegradable polymer matrix contains the first poly(D,L-lactide-co-glycolide) and the second poly(D,L-lactide-co-glycolide), moreover, the first poly(D,L-lactide-co-glycolide) has an ester end group and the ratio of D,L-lactide:glycolide, equals to 75:25, and the second poly(D,L-lactide-co-glycolide) has an acid end group and the ratio of D,L-lactide:glycolide is 50:50. Also a device for installing an intraocular implant is disclosed, method for treating a pathological condition of the eye using the intraocular implant, method for producing the intraocular implant, as well as the extruded biodegradable intraocular implant, further comprising sodium phosphate, polysorbate 20 and an antibody that binds vascular endothelial growth factor.

EFFECT: group of inventions provides continuous release of protein in a biologically active form for at least two months after the implant has been installed in the eye of a mammal.

14 cl, 8 dwg, 1 tbl, 3 ex