FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a pharmaceutical composition containing an APL type peptide identified as SEQ ID NO: 1, as an inhibitor of a hyperinflammation state, characterized by an increase in the levels of cytokines or interleukins and inflammation molecules, which increase their concentration to achieve a condition defined as a "cytokine storm". Concentrations of sucrose in said composition increase the biological activity of the peptide, facilitating its intravenous application.
EFFECT: said peptide in a pharmaceutical composition is useful for preparing a medicament for treating diseases associated with hyperinflammation, such as Covid-19, dengue fever, macrophage activation syndrome, respiratory sepsis, and with chimeric antigen receptor T-cell therapies, as well as acute respiratory distress syndrome.
11 cl, 2 dwg, 4 tbl, 9 ex
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Authors
Dates
2025-02-05—Published
2021-04-12—Filed