METHOD FOR PREDICTION OF OUTCOME OF ACUTE DISEASE CAUSED BY NEW CORONAVIRUS INFECTION COVID-19 Russian patent published in 2022 - IPC G01N33/68 G01N33/569 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to clinical and laboratory diagnostics, and can be used to predict the outcome of an acute disease caused by a novel coronavirus infection COVID-19 by blood plasma cytokine concentration. Prior to therapy, blood plasma concentrations of interleukin-6 (IL-6) and interleukin-18 (IL-18) are determined. At the first stage, the concentration of IL-18 is assessed, at the value of which is equal to or more than 81.6 pg/ml, a lethal outcome is predicted. If the value is less than 81.6 pg/ml, the second stage is carried out, at which the blood plasma concentration of IL-6 is evaluated, at the value of which is equal to or more than 23.5 pg/ml, a lethal outcome is predicted, less than 23.5 pg/ml — recovery is predicted.

EFFECT: method enables expanding the range of agents used to predict the outcome of an acute disease caused by a novel coronavirus infection COVID-19, which allows to divide patients into two groups: recovered patients and patients with lethal outcome, due to determination of two cytokines in blood plasma before the beginning of therapy: IL-6 and IL-18.

1 cl, 1 dwg, 3 ex