METHOD FOR ASSESSING RADIATION SAFETY OF RADIOPHARMACEUTICAL PREPARATION "ALBUMIN MICROSPHERES LABELLED WITH Re" DURING RADIOSYNOVECTOMY OF KNEE JOINT Russian patent published in 2025 - IPC G01N33/49 A61K47/42 A61M36/00 A61P19/02 

FIELD: medicine; biotechnology.

SUBSTANCE: disclosed is a method for assessing the radiation safety of the radiopharmaceutical "Albumin microspheres labelled with ¹⁸⁸Re" during radiosynovectomy of the knee joint, including, before the introduction of the radiopharmaceutical drug (RPD), the patient's peripheral blood sampling in amount of 10 ml – "day 0", then on 3rd day after the introduction of the RPD "day 3"; then cytogenetic preparations for biological dosimetry are prepared by the method of chromosome type aberration analysis on a light microscope: paired fragments, centric rings and dicentrics with a total number of analysed metaphases per sample of not less than 300, and calculating the frequency of aberrations F by a given formula; induction of radiation markers ΔF is calculated as the frequency difference on "day 3" and "day 0", biological dosimetry is performed with estimation of the incidental dose of total internal radiation D, and if gain ΔF due to introduction of RPD does not differ from zero, as well as calculated dose D, the examined patient does not belong to the group of radiation risk from side effects of RPD.

EFFECT: invention provides a wider range of methods for assessing the radiation safety of patients when performing a radiosynovectomy of the knee joints RPD "5-10 mcm albumin microspheres labelled with ¹⁸⁸Re" when administered intra-articularly.

1 cl, 2 dwg, 3 ex