METHOD OF PRODUCING LIPOSOMAL DOSAGE FORM OF ACETYLCYSTEINE Russian patent published in 2025 - IPC A61K9/127 A61K31/198 

Abstract RU 2836760 C1

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention refers to pharmacology and medicine, namely to a new type of dosage form of acetylcysteine, which is used as solutions for inhalations and solutions for injections for the purpose of treating bronchopulmonary diseases. Method of producing a liposomal dosage form of acetylcysteine consists in producing a liposomal dosage form by mixing lecithin and cholesterol, dissolving them using chloroform, drying until a lipid film is formed and chloroform completely disappears, further hydration with a solution of acetylcysteine in solution of 0.9 % sodium chloride, homogenisation of the resulting dispersion, purification by dialysis and subsequent assessment of the quantitative content of acetylcysteine, wherein the composition of the dosage form of acetylcysteine, which is both inside the liposomes, and outside the liposomes, wt.%: lecithin 6, cholesterol 0.06, intraliposomal acetylcysteine 1.37, extraliposomal acetylcysteine 8.63, sodium chloride 0.83, deionised water 83.11.

EFFECT: declared invention enables to reduce the amount of the drug preparation of acetylcysteine, increase the effectiveness of its use due to a new form of drug delivery, having lower toxicity compared to empty liposomes, which can be introduced into the body by different methods (intravenously, intraperitoneally and inhalation), providing its longer action due to the increased half-life of acetylcysteine, which allows to increase the survival rate of patients with acute respiratory distress syndrome and reduce the degree of pulmonary involvement.

1 cl

Similar patents RU2836760C1

Title Year Author Number
ANTIOXIDANT LIPOSOMAL COMPOSITION FIR INHALATION IN LUNG AND UPPER RESPIRATORY TRACT DISEASES 2006
  • Selishcheva Alla Anatol'Evna
  • Tikhonov Vladimir Petrovich
RU2315593C1
LIPOSOMAL PREPARATION OF DEXAMETHASONE IN HYPERTENSION SOLUTION OF SODIUM CHLORIDE AND METHOD FOR TREATMENT OF ACUTE LUNG DAMAGE ON ITS BASIS 2017
  • Inchina Vera Ivanovna
  • Pyataev Nikolaj Anatolevich
  • Ageev Valentin Pavlovich
  • Kulikov Oleg Aleksandrovich
RU2667467C1
AGENT WITH LIPOSOMES CONTAINING GLUTAMIC ACID AND PROPOLIS EXTRACT, EXHIBITING NOOTROPIC ACTIVITY 2015
  • Shikova Yuliya Vitalevna
  • Simonyan Elena Vladimirovna
  • Likhoded Vitalij Alekseevich
  • Yumaguzhina Alina Timeryanovna
  • Vladimirov Ivan Aleksandrovich
  • Bakhtiyarova Svetlana Bikmukhametovna
RU2589280C1
MEDICATION FOR PHOTODYNAMIC THERAPY, METHOD OF OBTAINING CLAIMED MEDICATION AND METHOD OF CARRYING OUT PHOTODYNAMIC THERAPY WITH APPLICATION OF CLAIMED MEDICATION 2010
  • Baryshnikov Anatolij Jur'Evich
  • Loshchenov Viktor Borisovich
  • Meerovich Gennadij Aleksandrovich
  • Orlova Ol'Ga L'Vovna
  • Oborotova Natal'Ja Aleksandrovna
  • Pozdeev Vitalij Igorevich
  • Polozkova Alevtina Pavlovna
RU2428981C1
LIPOSOMAL COMPOSITIONS USED FOR DRUG DELIVERY 2015
  • Hong Keelung
  • Drummond Daryl C.
  • Kirpotin Dmitri B.
RU2757110C2
METHOD OF OBTAINING MAGNETOSENSITIVE LIPOSOMES 2007
  • Fedushchak Taisija Aleksandrovna
  • Dambaev Georgij Tserenovich
  • Antipov Sergej Anatol'Evich
  • Khlusov Igor' Al'Bertovich
  • Ermakov Anatolij Egorovich
  • Ujmin Mikhail Aleksandrovich
  • Itin Volja Isaevich
RU2357724C1
PREPARATION WITH LIPOSOMES, CONTAINING SUCCINIC ACID AND PROPOLIS EXTRACT, POSSESSING DISINTOXICATION AND ANTIOXIDANT ACTIVITY 2014
  • Shikova Julija Vital'Evna
  • Simonjan Elena Vladimirovna
  • Likhoded Vitalij Alekseevich
  • Ermolaev Andrej Dmitrievich
  • Chernov Aleksandr Vladimirovich
  • Grigor'Eva Galina Pavlovna
  • Jumaguzhina Alina Timer'Janovna
  • Bakhtijarova Svetlana Bikmukhametovna
  • Zaripov Rinat Amirjanovich
RU2561591C1
AGENT WITH LIPOSOME CONTAINING ALBUMIN AND PROPOLIS EXTRACT, EXHIBITING REPARATIVE ACTIVITY IN ANAEMIAS HAEMORRHAGIC 2015
  • Shikova Yuliya Vitalevna
  • Simonyan Elena Vladimirovna
  • Likhoded Vitalij Alekseevich
  • Sinitskij Anton Ivanovich
  • Osikov Mikhail Vladimirovich
  • Zaripov Rinat Amiryanovich
RU2599505C1
AGENT WITH LIPOSOMES CONTAINING NICOTINIC ACID AND PROPOLIS EXTRACT HAVING DETOXIFICATION AND ANTIOXIDANT ACTIVITY 2014
  • Shikova Yuliya Vitalevna
  • Simonyan Elena Vladimirovna
  • Likhoded Vitalij Alekseevich
  • Yumaguzhina Alina Timeryanovna
  • Abramovskikh Kseniya Alekseevna
  • Bakhtiyarova Svetlana Bikmukhametovna
RU2585099C1
LIPOSOMAL COMPOSITION FOR APPLICATION IN PERITONEAL DIALYSIS 2013
  • Leru Zhan-Kristof
  • Forster Vinsent
RU2609860C2

RU 2 836 760 C1

Authors

Kulikov Oleg Aleksandrovich

Ageev Valentin Pavlovich

Piataev Nikolai Anatolevich

Markushova Evgeniia Vitalevna

Sinichkina Anna Denisovna

Dates

2025-03-21Published

2024-12-20Filed