LONG-TERM REABSORBABLE SUBCUTANEOUS IMPLANT WITH STABLE RELEASE OF PRE-CONCENTRATED PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR TREATING PARKINSON'S DISEASE Russian patent published in 2025 - IPC A61K31/6615 A61K47/30 A61P25/16 

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely to long-term absorbable subcutaneous implants with stable release of a pharmacologically active substance pre-concentrated in a polymer for treating Parkinson's disease. Long-term degradable subcutaneous implant with stable release of a pre-concentrated pharmacologically active substance in a polymer for treating Parkinson's disease is characterized by the presence in the biodegradable implant of 50-250 mg of nicotinamide adenine dinucleotide (NAD) in uniformly dispersed particles in a biodegradable and bioabsorbable polymer matrix, wherein the composition of the polymer matrix is 1-20% of the biodegradable polymer in proportion to the weight of nicotinamide adenine dinucleotide (NAD), and the implant is characterized by the presence of a polymer shell with thickness of 0.1 to 0.7 mm, and in which the biodegradable polymer is selected from the group of racemic polylactic acid and polyglycolic acid.

EFFECT: invention provides stable release of NAD for 6 months from a specific polymer matrix, characterized by a polymer coating with a specific thickness of 0.1-0.7 mm, which provides accurate control of drug release over time.

3 cl, 3 dwg