ORGANIC COMPOUNDS Russian patent published in 2022 - IPC C07D471/16 A61K31/4985 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention relates to a pharmaceutical composition for the treatment of a disease with involvement of one of paths of serotonin 5-HT_2A, dopamine D2, and/or serotonin reuptake transporter (hereinafter – SERT), including a compound of the formula I: , where: R¹ is CH₃ or CD₃; R² and R³, each independently, is H or D; R⁴ and R⁵, each independently, is H or D; provided that R², R³, R⁴, and R⁵ are not all H, when R¹ is CH₃, and where D is deuterium in a free form or in the form of pharmaceutically acceptable salt, in a combination or association with a pharmaceutically acceptable solvent or carrier, where the composition contains therapeutically effective amount of a compound of the formula I from 1 to 100 mg. The invention also relates to a method for the treatment or prevention of a disorder of the central nervous system with involvement of 5-HT_2A receptor, SERT, and/or paths including signal systems D₁/D₂ of dopamine receptors, including administration to a patient who needs it of therapeutically effective amount of the compound of the formula I.

EFFECT: invention provides compounds, which partially limit metabolism of ketone and/or N-methyl substitute by introduction of deuterium atoms at different positions.

9 cl, 1 tbl