Show metadata Hide metadata

(19)

(11)

2 837 355

(13)

(51)

IPC

C07D403/14(2006-01-01)

A61K31/506(2006-01-01)

A61P1/04(2006-01-01)

A61P11/06(2006-01-01)

A61P17/00(2006-01-01)

A61P17/04(2006-01-01)

A61P19/02(2006-01-01)

(21) (22)

Application

2022127322, 2021-04-22

(24)

Start date

2021-04-22

(22)

Actual filing date

2021-04-22

(45)

Published

2025-03-31

(72)

Inventor

Congreve, Miles StuartFieldhouse, CharlotteSwain, Nigel AlanPickworth, MarkHannah, Duncan Robert

(73)

Holder

Nxera Pharma Uk Limited

H4 ANTAGONIST COMPOUNDS Russian patent published in 2025 - IPC C07D403/14 A61K31/506 A61P1/04 A61P11/06 A61P17/00 A61P17/04 A61P19/02

Abstract RU 2837355 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds having histamine H4 receptor antagonist activity. Disclosed is a compound selected from a group of compounds specified below, or a pharmaceutically acceptable salt thereof, as well as a pharmaceutical composition containing such a compound.

EFFECT: disclosed compounds combine histamine H4 receptor antagonism with low hERG activity and can be used to treat inflammatory diseases associated with H4 receptors.

9 cl, 1 dwg, 4 tbl, 43 ex

Similar patents RU2837355C1

Title	Year	Author	Number
OXADIAZOLES AS MUSCARINIC RECEPTOR AGONISTS M AND/OR M	2019	Brown Giles Albert Teobald Barry John Tehan Benjamin Gerald	RU2817018C2
6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEINKINASE INHIBITORS	2005	Arnol'D Li D. Sesario Kara Kout Khiter Krju Ehndrju Filip Dun Khan'Tsin Forman Kennet Khonda Ajako Laufer Radoslav Li An'-Khu Malvikhill Kristen Mishel' Malvikhill Mark Dzhozef Najgro Ehntoni Paniker Bidzhoj Shtajnig Arno G. Sun' Inchuan' Vehn Tsinkhua Verner Duglas S. Uajl Majkl Dzh. Chzhan Tao	RU2379308C2
COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS	2016	Dzhons Elison Kemp Mark Stokli Martin Gibson Karl Uitlok Gevin	RU2717238C2
BICYCLIC NITROGEN-CONTAINING COMPOUNDS AS AGONISTS OF M1 MUSCARINIC RECEPTORS	2019	Brown Giles Albert Cansfield Julie Elaine Congreve Miles Stuart O'Brien Michael Alistair Pickworth Mark Rackham Mark David Tehan Benjamin Gerald Teobold Barry John	RU2811601C1
PHARMACEUTICAL COMPOUNDS	2018	Brown Giles Albert Cansfield Julie Congreve Miles Stuart Tehan Benjamin Gerald Teobald Barry John	RU2767857C2
HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS	2010	Arndt Dzhozef Chan Timoti Gukian Kevin Kumaravel Gianasambandam Li Ven-Cherng Lin Edvard In-Shian Skott Deniel Sun Likhun Tomas Dzhermejn Van Vloten Kurt Van Depin Chzhan Lej Erlanson Deniel	RU2615130C2
1,2,4-TRIAZINE-3-AMINE DERIVATIVES	2011	Kongriv Majlz Styuart Endryus Stiven Filipp Mejson Dzhonatan Stiven Richardson Kristin Meri Braun Zhajls Albert	RU2771819C2
PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA	2013	Achab Abdelgkhani Abe Altman Majkl D. Deng Jongki Kattar Solomon Katts Dzhejson D. Metot Dzhon L. Chzhou Khua Makgovan Meredet Kristofer Mettyu P. Garsiya Yudit Entoni Nevill Dzhon Fradera Linas Fransesk Ksaver Yan Lipin Mu Chanvej Van Syaona Shi Fen E Bajtszyun Chzhan Sisin Chzhao Syaoli Chzhan Zhun Fong Kin Chiu Len Syanshen	RU2661896C2
HETEROARYL-BIPHENYL AMINES FOR TREATING PD-L1 DISEASES	2020	Fan, Pingchen Lange, Christopher W. Lui, Rebecca M. Mcmurtrie, Darren J. Scamp, Ryan J. Yang, Ju Zeng, Yibin Zhang, Penglie	RU2837843C1
3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF	2013	Sagara Takesi Ito Satoru Otsuki Satie Sootome Khirosi	RU2576384C1

RU 2 837 355 C1

Authors

Congreve, Miles Stuart

Fieldhouse, Charlotte

Swain, Nigel Alan

Pickworth, Mark

Hannah, Duncan Robert

Dates

2025-03-31—Published

2021-04-22—Filed