OXADIAZOLES AS MUSCARINIC RECEPTOR AGONISTS M AND/OR M Russian patent published in 2024 - IPC C07D413/14 C07D451/02 C07D451/14 C07D453/06 C07D471/10 C07D487/10 C07D498/08 C07D498/10 A61K31/5386 A61K31/454 A61K31/46 A61K31/4245 A61K31/55 A61P25/28 A61P29/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (1) or a pharmaceutically acceptable salt thereof, where X¹ and X² are saturated hydrocarbon groups, containing together in total from five to nine carbon atoms and zero or one oxygen atom and bonded together so that the fragment forms a monocyclic or bicyclic ring system, or where X¹ and X² are connected together so that the fragment forms , X³ and X⁴ are saturated hydrocarbon groups, containing in total from three to six carbon atoms and bonded together in such a way that the fragment forms a monocyclic or bicyclic ring system, R¹ is selected from NR⁵R⁶, CONR⁵R⁶, COOR⁷, 5- or 6-member ring containing 0, 1 or 2 heteroatoms selected from N, which is optionally substituted with C₁-C₃ alkyl, CONR⁵R⁶, halogen, oxo, CH₂OH or pyrazole ring substituted with C₁-C₃ alkyl, or R¹ is bonded to R² to form a monocyclic or bicyclic ring containing 1 or 2 heteroatoms selected from O and N, which is substituted with one or more substitutes selected from C₁-C₆ alkyl and oxo, R² is selected from hydrogen and cyano, R⁴ is a C_1-6 alkyl group, optionally substituted with one or more fluorine atoms, R⁵ is selected from COCH₃, a non-aromatic C_1-10 saturated hydrocarbon group, optionally substituted with one or more fluorine atoms, R⁶ is selected from hydrogen and non-aromatic C_1-10 saturated hydrocarbon group and R⁷ is a non-aromatic C_1-6 saturated hydrocarbon group. Invention also relates to a pharmaceutical composition having M₁ and/or M₄ muscarinic receptor agonist activity based on the compound of formula (1).

EFFECT: obtaining novel compounds and a pharmaceutical composition based on them, which can be used in medicine in treating diseases mediated by muscarinic receptors M₁ and / or M₄, such as Alzheimer's disease, Lewy body dementia, pain.

23 cl, 4 tbl