FIELD: pharmaceutics.
SUBSTANCE: group of inventions refers to a pharmaceutical combination containing an SFRP2 antagonist and a PD-1 antibody antagonist. There are presented a method, a kit, a pharmaceutical composition for treating osteosarcoma, based on using a therapeutically effective amount of a humanised monoclonal antibody to SFRP2 and a therapeutically effective amount of nivolumab. Humanized monoclonal antibody to SFRP2 contains V-regions of murine monoclonal antibody 80.8.6, constant regions of heavy chain IgG1 and constant regions of light chain κ.
EFFECT: inventions provide effective inhibition of metastatic osteosarcoma growth in vivo.
15 cl, 14 dwg, 3 ex
| Title |
Year |
Author |
Number |
| REDUCTION OF TUMOR MASS BY INJECTING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS |
2017 |
- Sharo Izrael
- Chon Khejyun
- Shall Tomas Dzh.
- Chzhan Penli
|
RU2745195C2 |
| COMBINATION OF PD-1 ANTAGONIST, VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR AND CBP/BETA-CATENIN INHIBITOR FOR TREATING CANCER |
2020 |
- Ozawa, Yoichi
- Funahashi, Yasuhiro
- Kato, Yu
|
RU2838452C1 |
| METHODS OF TREATING CANCER USING PD-1 AND PD-L1 ANTAGONISTS IN COMBINATION WITH RADIATION THERAPY |
2015 |
- Stewart, Ross
- Morrow, Michelle
- Wilkinson, Robert
- Poon, Edmund
- Dovedi, Simon
- Illidge, Tim
|
RU2711408C2 |
| TREATING LUNG CANCER BY COMBINATION OF ANTI-PD-1 AND OTHER ANTI-CANCER AGENTS |
2015 |
- Feltquate David
- Chen Allen C.
|
RU2695332C2 |
| IMMUNE ENHANCING AGENT FOR TREATING A MALIGNANT NEOPLASM WITH USING AN ALLERGIN-1 ANTAGONIST |
2016 |
- Sibayama, Siro
- Arima, Khirosi
- Simbo, Takuya
|
RU2734777C2 |
| COMBINED METHODS FOR TREATING WITH PD-L1 ANTAGONISTS |
2016 |
- Endryus Glen Ajan
- Chen Shikhao
- Di Petro Alessandra
- Fontana Dejvid
- Goldberg Zelanna
- Lin Chia-Yan
- Long Khua
- Martinoni Marsella
- Nujten Dmitrij Serzh Antuan
- Toll Aron Dejvid
- Vulfson Adrian
|
RU2766890C2 |
| USE OF INHIBITORS OF IMMUNE CONTROL POINTS IN NEW GROWTHS OF CENTRAL NERVOUS SYSTEM |
2015 |
- Coric, Vladimir
- Cheng, Shinta
|
RU2726996C1 |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
- Kezada, Serkhio
- Peggs, Karl
- Arse Vargas, Frederik
|
RU2759970C2 |
| METHODS OF TREATING CANCER USING PD-1 AXIS BINDING AND VEGF ANTAGONISTS |
2013 |
- Maecker Heather
- Irving Bryan
|
RU2689760C2 |
| METHODS FOR TREATING CANCER, INCLUDING TIGIT-BINDING AGENTS |
2017 |
- Dyupon, Dzhejkob
- Parmar, Khema
|
RU2765410C2 |
