METHODS OF TREATING CANCER USING PD-1 AND PD-L1 ANTAGONISTS IN COMBINATION WITH RADIATION THERAPY Russian patent published in 2020 - IPC A61K39/395 A61P35/00 

Abstract RU 2711408 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and concerns a method of treating cancer in a patient, comprising administering to said patient at least one fractional radiation therapy fraction; administering to said patient at least one PD-1 and/or PD-L1 antibody, wherein at least one PD-1 and/or PD-L1 antibody is administered on the same day as the radiation therapy fraction, or for a period of not more than 4 days, inclusive, where said fraction is 2.2 Gy or less and where the cancer is bladder cancer, breast cancer, colorectal cancer, head and neck cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer or kidney cancer.

EFFECT: invention provides higher cancer survival.

17 cl, 11 dwg, 1 tbl, 1 ex

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RU 2 711 408 C2

Authors

Stewart, Ross

Morrow, Michelle

Wilkinson, Robert

Poon, Edmund

Dovedi, Simon

Illidge, Tim

Dates

2020-01-17Published

2015-06-17Filed