METHOD FOR PREDICTING POSSIBILITY OF SURGICAL TREATMENT IN SCOPE OF RECONSTRUCTIVE SPINAL INTERVENTION IN PATIENTS WITH TUBERCULOUS SPONDYLITIS COMBINED WITH VIRAL INFECTIONS Russian patent published in 2025 - IPC G01N33/68 G01N33/49 G01N33/573 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely phthisiology, and can be used to predict the possibility of surgical treatment within the scope of reconstructive spinal intervention in patients with tuberculous spondylitis combined with viral infections. Venous blood is sampled from a surgical candidate. In the patient's venous blood serum, the concentration of interleukin 10 (IL10), interleukin 6 (IL6) is determined by enzyme immunoassay, tumour necrosis factor-alpha (TNFα), D-dimer, troponin I. Results of clinical studies are substituted into the logistic regression equation: y=x₁+x₂+x₃-x₄-x₅, where y is operability index, standard units; x₁ is IL10: interleukin-10, pg/ml; x₂ is IL6: interleukin-6, pg/ml; x₃ is TNFα: tumour necrosis factor-alpha, pg/ml; x₄ is D-dimer, ng/ml; x₅ is troponin I, ng/ml. If y is greater than or equal to −195, the possibility of surgical treatment is predicted. If the y value is less than −195, the surgical treatment cancellation or postponement is predicted.

EFFECT: method provides more effective prediction of the possibility of performing a radical reconstructive surgical intervention on the spine in patients with tuberculous spondylitis combined with viral infections, including HIV infection and hepatitis B/C, due to blood concentration of IL10, IL6, TNFα, D-dimer and troponin I.

1 cl, 2 ex