COMBINATION OF BI853520 WITH CHEMOTHERAPEUTIC AGENTS Russian patent published in 2025 - IPC A61K31/506 A61K31/337 A61K31/704 A61K33/243 A61K9/127 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions refers to pharmaceutics, namely to the use of BI853520 or a pharmaceutically acceptable salt thereof in preparing a drug for treating a tumour in a combination with a chemotherapeutic agent, and to a pharmaceutical combination for treating a tumour. Use of BI853520 or a pharmaceutically acceptable salt thereof in the manufacture of a drug for treating a tumour in a combination with a chemotherapeutic agent, wherein BI853520 has the following structural formula:

wherein the chemotherapeutic agent is PLD, wherein the tumour is ovarian cancer. Pharmaceutical combination for treating a tumour, comprising BI853520 or a pharmaceutically acceptable salt thereof and a chemotherapeutic preparation, wherein BI853520 has the structural formula presented below, the chemotherapeutic agent is PLD, the tumour is ovarian cancer.

EFFECT: said group of inventions makes it possible to increase the effectiveness of chemotherapy and to overcome the problem of drug resistance.

6 cl, 8 dwg, 12 tbl, 6 ex