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2 838 512

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IPC

A61K9/20(2006-01-01)

A61K31/7068(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2024104436, 2024-02-21

(24)

Start date

2024-02-21

(22)

Actual filing date

2024-02-21

(45)

Published

2025-04-17

(72)

Inventor

Zolotov Sergej AnatolevichSinyavin Andrej EduardovichLujksaar Sergej IgorevichShastina Natalya SergeevnaSheremet Anna BorisovnaRemizov Timofej AndreevichZakharova Anastasiya AndreevnaSoloveva Anna VladimirovnaBondareva Nataliya EvgenevnaVasina Darya VladimirovnaAntonova Nataliya PetrovnaKlejmenov Denis AleksandrovichPochtovyj Andrej AndreevichKuznetsova Nadezhda AnatolevnaUsachev Evgenij ValerevichTokarskaya Elizaveta AleksandrovnaLubenets Nadezhda LeonidovnaLogunov Denis YurevichZigangirova Nailya AkhatovnaGushchin Vladimir AlekseevichGintsburg Aleksandr Leonidovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Issledovatelskij Tsentr Epidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Im. N.F. Gamalei" Minzdrava Rossii)

PHARMACEUTICAL COMPOSITION CONTAINING 5'-O-(3-PHENYLPROPIONYL)-N4-HYDROXYCYTIDINE Russian patent published in 2025 - IPC A61K9/20 A61K31/7068 A61P31/12

Abstract RU 2838512 C1

FIELD: medicine.

SUBSTANCE: present invention relates to medicine and chemical-pharmaceutical industry, namely to a new pharmaceutical composition containing 5'-O-(3-phenylpropionyl)-N4-hydroxycytidine for treating and/or preventing viral infections, which is a tablet, and containing 5'-O-(3-phenylpropionyl)-N4-hydroxycytidine in amount of 70-80% by weight of composition, disintegrant in amount of 2-6% of the weight of the composition, glidant in an amount of up to 1% of the weight of the composition, a binder in amount of 3-7% of the weight of the composition, lubricant in an amount of up to 1% of the weight of the composition, a filler in an amount of up to 15% of the weight of the composition.

EFFECT: invention provides a high level of solubility, as well as an increase in the biological availability of the API SN9, which in turn makes it possible to increase the effectiveness of the therapy using said drug substance.

6 cl, 1 dwg, 16 tbl, 3 ex

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RU 2 838 512 C1

Authors

Zolotov Sergej Anatolevich

Sinyavin Andrej Eduardovich

Lujksaar Sergej Igorevich

Shastina Natalya Sergeevna

Sheremet Anna Borisovna

Remizov Timofej Andreevich

Zakharova Anastasiya Andreevna

Soloveva Anna Vladimirovna

Bondareva Nataliya Evgenevna

Vasina Darya Vladimirovna

Antonova Nataliya Petrovna

Klejmenov Denis Aleksandrovich

Pochtovyj Andrej Andreevich

Kuznetsova Nadezhda Anatolevna

Usachev Evgenij Valerevich

Tokarskaya Elizaveta Aleksandrovna

Lubenets Nadezhda Leonidovna

Logunov Denis Yurevich

Zigangirova Nailya Akhatovna

Gushchin Vladimir Alekseevich

Gintsburg Aleksandr Leonidovich

Dates

2025-04-17—Published

2024-02-21—Filed