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(19)

RU

(11)

2 455 286

(13)

C2

(51)

IPC

C07D237/32(2006-01-01)

C07D403/10(2006-01-01)

C07D403/12(2006-01-01)

C07D401/10(2006-01-01)

C07D413/12(2006-01-01)

A61K31/495(2006-01-01)

A61K31/50(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009128984/04, 2007-12-20

(24)

Start date

2007-12-20

(22)

Actual filing date

2007-12-20

(45)

Published

2012-07-10

(72)

Inventor

Gandkhi Viradzh B.Zhiranda Vinsent L.Gun Tszjan'Chun'Penning Tomas D.Chzhu Guj-Dun

(73)

Holder

Ehbbott Lehboretriz

POLY(ADP-RIBOSO)POLYMERASE INHIBITORS Russian patent published in 2012 - IPC C07D237/32 C07D403/10 C07D403/12 C07D401/10 C07D413/12 A61K31/495 A61K31/50 A61P35/00 

Abstract RU 2455286 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes poly(ADP-riboso)polymerase inhibitors of formula (Ik) its pharmaceutically acceptable salt wherein R101, R104 and R105 represent H; R102 represents R11 wherein R11 is specified from pyrrolidinyl, oxazolyl, imidazolidinyl, isothiazolidinyl, piperidinyl, piperazinyl and azepanyl with R102 being substituted by one or two (O) substitutes; R103 represents fluorine, besides, a pharmaceutical composition on the basis of said compounds showing poly(ADP-riboso)polymerase (PARP) inhibitory activity, a method of treating cancer and a method of reducing tumour volume in a mammal.

EFFECT: there are produced and described new compounds which show poly(ADP-riboso)polymerase (PARP) inhibitory activity.

9 cl, 491 ex, 2 tbl

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RU 2 455 286 C2

Authors

Gandkhi Viradzh B.

Zhiranda Vinsent L.

Gun Tszjan'Chun'

Penning Tomas D.

Chzhu Guj-Dun

Dates

2012-07-10—Published

2007-12-20—Filed

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