CONDENSED PYRIDAZINE DERIVATIVES AND DRUGS HAVING THE COMPOUNDS AS ACTIVE INGREDIENTS Russian patent published in 2007 - IPC C07D237/32 C07D237/26 C07D471/04 C07D513/04 C07D487/04 C07D401/12 C07D403/12 C07D405/12 C07D409/12 C07D417/12 C07D401/04 C07D405/04 C07D417/04 C07D401/06 A61K31/502 A61K31/5025 A61K31/53 A61K31/554 A61K31/542 A61K31/5377 A61K31/551 A61P9/10 A61P25/28 A61P35/00 A61P37/00 A61P37/06 

FIELD: medicine.

SUBSTANCE: compound is represented by structural formula

or its pharmaceutically permissible salts, where R1 is the hydrogen atom (1), C_1-8acyl(2), hydroxyl (3), halogen atom (5), C_2-8acyl (3), C_1-8-alcocsy (4), substituted with phenyl or C_2-8acyl, substituted with NR²R³; R²R³ independently represent hydrogen atom (1) or C_1-8acyl(2), X and Y each independently representing C (1), CH (2) or N (3). is (1) single or (2) double bond. is 5-7-member carbocyclic group or 5-7-member partially or fully saturated heterocyclic group defined in claim 1 of invention. A is one of A¹ to A⁵ groups defined by claim 1 of the invention. The compounds show inhibiting properties relative to poly(ADP-ribose)polymerase are usable as prophylactic and/or curative drugs for treating ischemic diseases (in brain, spinal cord, heart, digestive tract, skeletal muscle, eye retina, e.t.c.), inflammatory diseases (intestinal inflammation, disseminated sclerosis, arthritis, e.t.c.), neurodegenerative disorders (extrapyramidal disorder, Alzheimer disease, muscle dystrophy, cerebrospinal canal stenosis in lumbar segment of the vertebral column, e.t.c.), diabetes, stroke, cerebral injury, hepatic insufficiency, hyperalgesia, e.t.c. The compounds are also of use in struggling against retroviruses (HIV and others), as sensitizing agents for treating cancer cases and immunodepressant agents.

EFFECT: enhanced effectiveness of treatment.

19 cl, 90 tbl