FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology, particularly to a recovered antibody or its antigen-binding fragment able to specifically bind to fibroblast growth factor receptor 2b (FGFR2b), to a method for preparing it, as well as to a conjugate and a composition containing it. Also disclosed is an isolated polynucleotide encoding said antibody or a fragment thereof, as well as a host cell and a vector containing same. Invention also relates to the diagnosis of a disease or condition associated with FGFR2b, as well as to a method for predicting a disease or condition associated with FGFR2b, in a subject, providing the use of the above antibody or a fragment thereof.
EFFECT: invention is effective for treating a disease or condition associated with FGFR2b in a subject.
39 cl, 9 dwg, 3 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL ANTI-FGFR2B ANTIBODIES | 2020 |
|
RU2840537C1 |
| NOVEL ANTI-FGFR2B ANTIBODIES | 2020 |
|
RU2840536C1 |
| HUMANISED HUMAN CD19 ANTIBODIES AND METHODS FOR USE THEREOF | 2016 |
|
RU2731156C1 |
| ANTI-TFR ANTIBODIES AND USE THEREOF IN TREATING PROLIFERATIVE AND INFLAMMATORY DISORDERS | 2016 |
|
RU2737637C2 |
| NOVEL ANTI-CLDN18.2 ANTIBODIES | 2020 |
|
RU2830887C2 |
| ANTI HUMAN INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (IL1RAP) ANTIBODIES AND USES THEREOF | 2015 |
|
RU2710787C2 |
| AFUCOSYLATED FIBROBLAST GROWTH FACTOR FGFR2IIIB RECEPTOR | 2014 |
|
RU2740714C2 |
| ANTI-PD-1 ANTIBODIES | 2017 |
|
RU2752832C2 |
| ANTIBODIES AGAINST TRANSFERRIN RECEPTOR HAVING INDIVIDUALIZED AFFINITY | 2016 |
|
RU2729416C2 |
| ANTIBODIES OF DOGS WITH MODIFIED CH2-CH3 SEQUENCES | 2014 |
|
RU2687209C1 |
