SUBSTITUTED 1,2-DIHYDRO-5-MORPHOLINO-4H-PYRANO-[4′,3′:4,5]-PYRIDO-[2,3-B]-THIENO-[3,2-D]-PYRIMIDINE-8(9H)-ONE OR -[9,11]-OXAZINE-8-ONE SHOWING ANTIBACTERIAL EFFECT Russian patent published in 1995 - IPC

FIELD: fused heterocyclic compounds. SUBSTANCE: product: 1,2-dihydro-2,2-dimethyl-5-morpholino-4H-pyrano-[4′,3:4,5: 4,5] -pyrido-[2,3-b]-thieno-[3,2-d] -pyrimidine-8(9H)-one (I) or 1,2-dihydro-5-morpholino-8-oxo-2,2,10-trimethyl-4H-pyrano-[$$-$: 4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-[9,11]-oxazine (II). Synthesis of (I) is carried out by boiling 3-amino-2-carbethoxy-5,5-dimethyl-8-(N-morpholino)-4,5-dihydro-7H-pyrano-[4,3-d]-thieno-[2,3-b]-pyridine and formamide for 2 h and precipitate is separated. The yield is 85.5% m. p. is 371-372 C, R_f 0.68 (in dimethylformamide-ether, 2:5). Synthesis of (II) is carried out by boiling 3-amino-5,5-dimethyl-8-morpholino-2-carbethoxy-4,5-dihydro-7H- -pyrano-[4,3-d] -thieno-[2,3-b]-pyridine in the medium of (CH₃CO)₂O for 1 h. Precipitate is separated after cooling. The yield of (II) is 68.4% m. p. is 301-302 C. Effectiveness of (I) and (II) against staphylococcus and dysentery bacillus is at the level that of norsulfazole but at dysentery septicemia their effect is lower. EFFECT: improved method of synthesis. 1 tbl