FIELD: heterocyclic compounds. SUBSTANCE: product: 5-morpholino- 2,2,10- trimethyl-8- phenyl-1,2- dihydro-4H- pyran- o-[4',3':4,5-] -pyrido-[2,3-b] thieno-[3,2-b] pyridine-9-carboxylic acid. Synthesis of new heterocyclic system is carried out from 3-amino-2- benzoyl-5,5- dimethyl-4,5- dihydro-8- morpholino-7H- pyrano- [4',3':4,5] pyrido-[2,3-b] thiophene and acetoacetic acid ethyl ester in the presence of ZnCl2 in the medium of m-xylene at boiling and distilling off aqueous azeotrope. The yield is 82.2% empirical formula is C27H27N3O4S. Activity is reached at the dose 200 mg/kg, maximally tolerated dose is 3000 mg/kg. Synthesized compound shows anticonvulsant activity and low toxicity. EFFECT: increased yield of product, low toxicity.
| Title |
Year |
Author |
Number |
| HYDROCHLORIDE 7H-4,5- DIHYDRO-3- AMINO-5,5- DIMETHYL-8- MORPHOLINOIZOTIAZOLO [5',4'-2,3] PYRIDO[4,5-C]PYRAN POSSESSING ANTICONVULSIVE ACTIVITY |
1984 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Vartanjan S.A.
- Dzhagatspanjan I.A.
- Nazarjan I.M.
|
SU1235185A1 |
| SUBSTITUTED 1,2-DIHYDRO-5-MORPHOLINO-4H-PYRANO-[4′,3′:4,5]-PYRIDO-[2,3-B]-THIENO-[3,2-D]-PYRIMIDINE-8(9H)-ONE OR -[9,11]-OXAZINE-8-ONE SHOWING ANTIBACTERIAL EFFECT |
1985 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Vartanjan S.A.
- Ter-Zakharjan Ju.Z.
- Oganjan Sh.G.
|
SU1282510A1 |
| 1-AMINO-8,9-DIHYDRO-5,8,8-TRIMETHYL-3,6H-PYRAZOLO(3,4-b)THIOP- YRANO(4,3-D)PYRIDINE OR ITS HYDROCHLORIDE SHOWING ANTICONVULSANT ACTIVITY |
1989 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1626648A1 |
| 2,2-DIMETHYL-1,2-DIHYDRO-5-(N-MORPHOLINE)-8-CHLOR OR PHENYLHYDRAZINO-4H-PIRANO[4′,3′:4,5]PYRIDO[2,3-B]THIENO[3,2-D]-9,10,11-TRIAZINES HAVING ANTITUMOR ACTION |
1988 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1570274A1 |
| DERIVATIVES OF 2,2-DIMETHYL-1,2-DIHYDRO-4H-PYRANO-[4,3D]-FURO-[2,3-B]-PYRIDINE SHOWING ANTITUMOR ACTIVITY |
1990 |
- Paronikjan E.G.
- Oganesjan A.Kh.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1786804A1 |
| 5-SUBSTITUTED 1-AMINO-8,9- DIHYDRO-8,8- DIMETHYL-3,6H- PYRAZOLO-[3,4-B]- PYRANO-[4',3'-D]- PYRIDINE OR THEIR HYDROCHLORIDES SHOWING ANTICONVULSANT ACTIVITY |
1988 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1540240A1 |
| 1-AMINO-8,9-DIHYDRO-5-MORPHOLINO-7,7,8-TRIMETHYL-2-ETHOXYCARB- ONYL-6H-THIENO-[2,3-C][2,7]-NAPHTHIRIDINE OR ITS DIHYDROCHLORIDE SHOWING MUTAGENIC ACTIVITY |
1989 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Paronikjan G.M.
- Sarkisjan T.P.
|
SU1640984A1 |
| 3-AMINO -2- CARBETHOXY -5,5- DIMETHYL-8- (N-MORPHOLINO) -4,5-DIHYDRO -7H-PYRANO (4,3-D)T IENO (2,3-B)PYRIDINE POSSESSING ANTIMUTAGEN ACTIVITY |
1984 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
- Akopjan L.G.
- Paronikjan G.M.
|
SU1184244A1 |
| 2-AMINO-5,5-DIMETHYL-4,5-DIHYDRO-7H-PYRANO-[4,3-D]-THIAZOLE SHOWING TRANQUILIZING ACTIVITY |
1987 |
- Paronikjan E.G.
- Noravjan A.S.
- Vartanjan S.A.
- Dzhagatspanjan I.A.
- Nazarjan I.M.
|
SU1441749A1 |
| 2-METHYLAMINO-4-OXO-3,6,6-TRIMETHYL-5,6-DIHYDRO-8H-PIRANO[4′,3′:4,5]TIENO[2,3-<D>]PYRAMIDIN OR ITS SALTS POSSESSING ANTICONVULSIVE ACTIVITY |
1983 |
- Noravjan A.S.
- Oganisjan A.Sh.
- Grigorjan G.O.
- Vartanjan S.A.
- Dzhagatspanjan I.A.
- Akopjan A.G.
- Akopjan N.E.
- Voronina T.A.
- Nerobkova L.N.
- Val'Dman A.V.
|
SU1132513A1 |
