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1 363 768

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IPC

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Application

4026085/04, 1986-01-13

(22)

Actual filing date

1986-01-13

(45)

Published

1995-03-20

(72)

Inventor

Zakhs V.Eh.Jakovlev I.P.Ivin B.A.Anisimova N.A.Shilova N.Ju.Pastushenkov L.V.

MALONIC ACID N-AROYLAMIDE METHYL ESTERS SHOWING HYPOTENSIVE ACTIVITY Russian patent published in 1995 - IPC

Abstract SU 1363768 A1

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from 2-(p-chlorophenyl- or toluoyl)-1,3-oxazine-4,6-dione and methanol at heating up to complete dissolving. Yield is about 100% , m. p. 137-138 C for (C11H10ClNO4) and 122-122.5 C for (C12H3NO4). Effect of new compounds is observed in 15 min after administration (dose is 0.25 mg/kg), maximal effect is observed in 2-3 h, total period of effect is more than 5 h. Toxicity LD50 by 3.4-4.2-fold lower as compared with known malonic acid N-thiobenzoylamide tert.-butyl ester. EFFECT: synthesis of compounds with increased activity. 2 tbl

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SU 1 363 768 A1

Authors

Zakhs V.Eh.

Jakovlev I.P.

Ivin B.A.

Anisimova N.A.

Shilova N.Ju.

Pastushenkov L.V.

Dates

1995-03-20—Published

1986-01-13—Filed

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