FIELD: organic chemistry. SUBSTANCE: synthesis of proposed compound can be carried out by two variants I: a) from 2,2-dimethyl-4-morpholino-2,3-dihydro-6H-pyrane, Br2 in chloroform medium at stirring and cooling up to -15 C (above 1 hr) and at 20 C (2.5 hr); b) from prepared product with thiourea in ethanol medium at boiling (8 hr); or II: by reaction of 2,2-dimethyltetrahydropyrane-4-one, sulfur, cyanamide and diethylamine in ethanol medium at boiling and stirring reaction mixture (1.5 hr). The yield of the end product is 42.6-53.5%; m. p. is 163-164 C (in ethanol); empirical formula is C8H12N2OS. The end product has toxicity LD50 = 760 mg/kg, anticorazol activity at the dose ED50 = 35 mg/kg. Neurotoxic effect (coordination injury in mice) is observed at the dose 310 mg/kg). Under condition of conflict situation water drinking is increased by 3-fold at the dose of proposed compound as compared with control. Known phazepam under the same conditions increases water drinking by 38-fold. EFFECT: enhanced activity of product. 2 tbl
| Title |
Year |
Author |
Number |
| 2-METHYLAMINO-4-OXO-3,6,6-TRIMETHYL-5,6-DIHYDRO-8H-PIRANO[4′,3′:4,5]TIENO[2,3-<D>]PYRAMIDIN OR ITS SALTS POSSESSING ANTICONVULSIVE ACTIVITY |
1983 |
- Noravjan A.S.
- Oganisjan A.Sh.
- Grigorjan G.O.
- Vartanjan S.A.
- Dzhagatspanjan I.A.
- Akopjan A.G.
- Akopjan N.E.
- Voronina T.A.
- Nerobkova L.N.
- Val'Dman A.V.
|
SU1132513A1 |
| 5-SUBSTITUTED 1-AMINO-8,9- DIHYDRO-8,8- DIMETHYL-3,6H- PYRAZOLO-[3,4-B]- PYRANO-[4',3'-D]- PYRIDINE OR THEIR HYDROCHLORIDES SHOWING ANTICONVULSANT ACTIVITY |
1988 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1540240A1 |
| 2-AMINO-5,5- DIMETHYL- 3-CYAN-4,5-DIHYDRO- 7H-PYRANO[3,4-C]8H -TIOPYRANTION-8 POSSESSING ANTICONVULSIVE ACTIVITY |
1983 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
- Dzhagatspanjan I.A.
- Nazarjan I.M.
|
SU1125961A1 |
| DERIVATIVES OF 2,2-DIMETHYL-1,2-DIHYDRO-4H-PYRANO-[4,3D]-FURO-[2,3-B]-PYRIDINE SHOWING ANTITUMOR ACTIVITY |
1990 |
- Paronikjan E.G.
- Oganesjan A.Kh.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1786804A1 |
| COMPOSITION FOR INJECTIONS BASED ON CRYSTALLINE β-MODIFICATION OF 7-BROM-1,3-DIHYDRO-5-(2-CHLORPHENYL)-2H-1,4-BENZODIAZEPIN-2-ONE EXHIBITING TRANQUILISING ACTION AND METHOD FOR PREPARING IT |
2010 |
- Morozov Jurij Nikolaevich
- Kolotilov Pavel Nikolaevich
- Shabatin Vladimir Petrovich
- Sergeev Gleb Borisovich
- Chernyshev Vladimir Vasil'Evich
- Voronina Tat'Jana Aleksandrovna
- Molodavkin Gennadij Matveevich
|
RU2440120C1 |
| 1-AMINO-8,9-DIHYDRO-5,8,8-TRIMETHYL-3,6H-PYRAZOLO(3,4-b)THIOP- YRANO(4,3-D)PYRIDINE OR ITS HYDROCHLORIDE SHOWING ANTICONVULSANT ACTIVITY |
1989 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1626648A1 |
| 3-AMINO -2- CARBETHOXY -5,5- DIMETHYL-8- (N-MORPHOLINO) -4,5-DIHYDRO -7H-PYRANO (4,3-D)T IENO (2,3-B)PYRIDINE POSSESSING ANTIMUTAGEN ACTIVITY |
1984 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
- Akopjan L.G.
- Paronikjan G.M.
|
SU1184244A1 |
| 8-METHYL-8-PHENYL-3-OXOTHIAZOLIDINO-[3,2-A]-PIPERAZINE OR ITS HYDROCHLORIDE SHOWING TRANQUILIZING ACTION |
1991 |
- Kurojan R.A.
- Snkhchjan G.M.
- Mkrtchjan A.K.
- Markosjan A.I.
- Engojan A.P.
- Dzhagatspanjan I.A.
- Asrjan A.B.
- Sukasjan R.S.
|
SU1829361A1 |
| 1,2,4-TRIAZOLO- [1,5-A] -8,8-DEMETHYL -8,9- DIHYDRO-10- CYAN-6H- PYRANO- [4′,3′:4,5] -PYRIDINE-5 (1H)-TION |
1983 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
|
SU1187440A1 |
| SUBSTITUTED 1,2-DIHYDRO-5-MORPHOLINO-4H-PYRANO-[4′,3′:4,5]-PYRIDO-[2,3-B]-THIENO-[3,2-D]-PYRIMIDINE-8(9H)-ONE OR -[9,11]-OXAZINE-8-ONE SHOWING ANTIBACTERIAL EFFECT |
1985 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Vartanjan S.A.
- Ter-Zakharjan Ju.Z.
- Oganjan Sh.G.
|
SU1282510A1 |
