COMPOSITION FOR INJECTIONS BASED ON CRYSTALLINE β-MODIFICATION OF 7-BROM-1,3-DIHYDRO-5-(2-CHLORPHENYL)-2H-1,4-BENZODIAZEPIN-2-ONE EXHIBITING TRANQUILISING ACTION AND METHOD FOR PREPARING IT Russian patent published in 2012 - IPC A61K31/5513 A61K9/08 A61P25/22 

Abstract RU 2440120 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to medicine, in particular to pharmacy. A composition for injections exhibiting tranquilising action contains the ingredients in the following proportions, wt %: crystalline β-modification of 7-brom-1,3-dihydro-5-(2-chlorphenyl)-2H-1,4-benzodiazepin-2-one - 0.05-0.15, polyvinylpyrrolidone - 0.50-1.20, "Tween-80" - 2.00-10.00, glycerine - 5.00-15.00, sodium pyrosulphite - 0.30-1.20, sodium hydrate solution - to pH 6.0-7.5, water - the rest. A method for preparing the composition consist in the fact that "Tween-80" and glycerine are mixed, heated to 70-90°C, and crystalline β-modification of 7-brom-1,3-dihydro-5-(2-chlorphenyl)-2H-1,4-benzodiazepin-2-one is dissolved. The prepared mixture is poured in the mixed aqueous solution of sodium pyrosulphite and polyvinylpyrrolidone heated to 40-90°C, cooled to room temperature, filtered, reduced to pH 6.0-7.5 with sodium hydrate solution, bottled and sterilised.

EFFECT: presented group of inventions provide a composition exhibiting improved anxiolytic action and decreased sedation in comparison with the composition based on pharmacopoeial phenazepam.

2 cl, 2 tbl, 4 ex

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RU 2 440 120 C1

Authors

Morozov Jurij Nikolaevich

Kolotilov Pavel Nikolaevich

Shabatin Vladimir Petrovich

Sergeev Gleb Borisovich

Chernyshev Vladimir Vasil'Evich

Voronina Tat'Jana Aleksandrovna

Molodavkin Gennadij Matveevich

Dates

2012-01-20Published

2010-11-19Filed