FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to novel biologically active substances of the class of N-heterylamides of 4-aryl-3-halo-2,4-dioxobutanoic acids. The compound is N-(2-thiazolyl)amide 3-bromo-2,4-dioxo-4-phenyl butanoic acid, having antimicrobial activity, of formula 
(1).
EFFECT: novel derivative of 4-aryl-3-halo-2,4-dioxobutanoic acid, having marked antimicrobial activity, as well as low toxicity.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-(2-THIAZOLYL)AMIDE OF 2-(2-OXO-3-INDOLINYLIDENE)HYDRAZINO-4-OXO-4-PHENYL-2-BUTENOIC ACID HAVING ANTIBACTERIAL AND ANALGESIC ACTIVITY | 2008 |
|
RU2401837C2 |
| N-(2-BENZOTHIAZOLYL)AMIDE 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL)-2-BUTENOIC ACID HAVING ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY | 2008 |
|
RU2396262C2 |
| N-(2-BENZOTHIAZOLYL)AMIDE OF 3-BROMO-2,4-DIOXO-4-(4-METHOXY PHENYL)BUTANOIC ACID, HAVING HYPOGLYCEMIC ACTIVITY | 2010 |
|
RU2455293C2 |
| 3-BROMO-4-(4-METHOXYPHENYL)-N-(5-METHYL-1,3,4-THIADIAZOL-2-YL)-2,4-DIOXOBUTANAMIDE, HAVING ANTIMICROBIAL ACTION | 2018 |
|
RU2717243C2 |
| SUCCINATE OF N-(2,4,6-TRIMETHYLPHENYL)AMIDE 2-(BETA-N,N-DIETHYLAMINO ETHYLAMINO)-4-OXO-4-(4-METHYYLPHENYL)-2-BUTENOIC ACID | 2009 |
|
RU2428412C2 |
| BIS{3-PHENYL-1-[2-(5-METHYL-1,3,4-THIADIAZOLYL)]CARBOXAMIDO-1,3-PROPANEDIONATO}MANGANESE HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTVITY | 2008 |
|
RU2396263C2 |
| HYDROCHLORIDE OF N-(2, 6-DIMETHYLPHENYL)AMIDE OF 2-(β-N,N-DIETHYLAMINE ETYLAMINO)-4-OXO-4-(4-ETHOXYPHENYL)-2-BUTENOIC ACID, HAVING LOCAL ANAESTHETIC ACTIVITY | 2009 |
|
RU2412159C2 |
| BIS{3-PHENYL-1-[2-(5-ETHYL-1,3,4-THIADIAZOLYL)]CARBOXAMIDO-1,3-PROPANEDIONATO}CADMIUM, POSSESSING HYPOGLYCEMIC ACTIVITY | 2008 |
|
RU2364591C1 |
| N-SUBSTITUTED AMIDES OF 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL) 2-BUTENOIC ACID, EXHIBITING ANTIMICROBIAL ACTIVITY | 2009 |
|
RU2429225C2 |
| BIS{3-PHENYL-1-[N-(3-PYRIDYL)CARBOXAMIDO]-1,3-PROPANDIONATO} CADMIUM, WHICH HAS ANTI-FLAMMATORY ACTIVITY | 2007 |
|
RU2342364C1 |
