FIELD: medicine. SUBSTANCE: desired product is prepared of 2-mercapto-4,5-di(p-chlorophenyl)imidazole and hydrobromide of 2-morpholine ethyl bromide. Reaction is carried out in aqueous ethanol in the presence of NaOH. Thus obtained green-yellow oil is crystallized during sustaining. Yield of the base is 82.9 %. Said base is converted into hydrochloride by treatment with HCl. Yield of desired product is 96 %, its melting point is 241 C, its toxicity is 627 mg per 1 kg of body weight. EFFECT: increases activity of desired product. 1 tbl
| Title |
Year |
Author |
Number |
| DIHYDROCHLORIDE OF 4,5-DI-(3′,4′-DIMETHOXYPHENYL)-2-MORPHOLINOETHYLTHIO IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1295709A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINOETHYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA AND ACCELERATING PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Basieva T.S.
- Smirnov A.V.
- Bobkov Ju.G.
- Lozinskij M.O.
- Katkova E.B.
|
SU1220306A1 |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-4-PHENYL IMIDAZOLE WHICH INCREASES PHYSICAL RESISTANCE AT THERMAL STRESS |
1986 |
- Tomchin A.B.
- Vinogradov V.M.
- Sumina Eh.N.
- Petushkov N.M.
|
SU1356420A1 |
| 4-(4'-METHOXYPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYLIMIDAZOLE DIHYDROCHLORIDE ENHANCING PHYSICAL RESISTANCE |
1986 |
- Vinogradov V.M.
- Tomchin A.B.
- Spivakova R.P.
- Katkov V.F.
|
SU1415725A1 |
| DIHYDROCHLORIDE OF 4-(4′-BROMOPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYL IMIDAZOLE HAVING PROTECTING ACTIVITY AGAINST STRESS |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1387374A1 |
| 8-METHOXY-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]- INDOLE MALATE SHOWING ANTIHYPOXIC ACTIVITY |
1988 |
- Tomchin A.B.
- Marysheva V.V.
- Katkov V.F.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1547280A1 |
| DICHLORIDE OF 2-ALLYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING STRESS PROTECTING ACTIVITY AND ACCELERATES PROCESSES OF RECOVERY AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
|
SU1327497A1 |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-5-ETHOXYBENZIMIDAZOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Dmitrukha V.S.
- Vinogradov V.M.
- Spivakova R.P.
- Katkov V.F.
- Bobkov Ju.G.
|
SU1262926A1 |
| 2-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO(6,5-b)INDOL HYDROCHLORIDE POSSESSING ANTIHYPOXIC AND ANTIINFLAMMATORY ACTIVITY |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Poskalenko A.N.
- Ponomareva M.M.
|
SU1014250A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
