FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(2-aminoethylthio)-1,2,4-triazino-[5,6-b]-indole. Synthesis is carried out from 3-mercapto-1,2,4-triazino-[5,6-b] -indole and β-bromoethylamine bromohydrate at 50 C. Empirical formula is C11H11N5S, yield is 74.2%, m. p. is 245 C. Toxicity LD50 = 12.25 mg/kg. At hypercapnic hypoxia (at increased CO2 content) new compound provides 100% survival as compared with 25% in known bemithyl toxicity of which LD50 = 2.25 mg/kg. Synthesized compound can be used in medicine. EFFECT: new compound with enhanced activity. 2 tbl
| Title |
Year |
Author |
Number |
| 3-(MORPHOLINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE ENHANCING RESISTANCE TO HYPERCAPNIC HYPOXIA |
1989 |
- Turzhova E.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
|
SU1596719A1 |
| 3-ETHYLTHIO-5-(2-DIETHYLAMINO)-ETHYL-1,2,4-TRIAZINO(5,6-b)INDOL DIHYDROCHLORIDE POSSESSING ANTIINFLAMMATORY ACTIVITY AND INCREASING RESISTANCE OF ORGANISM TO OXYGEN INSUFFICIENCY |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Poskalenko A.N.
- Ponomareva M.M.
- Basieva T.S.
|
SU1032758A1 |
| DIHYDROCHLORIDE OF 3-(2-DIMETHYLAMINO)ETHYLAMINO-1,2,4-TRIAZINO(5,6-B)INDOLE IMPROVING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Makeev B.L.
|
SU1235181A1 |
| DIHYDROCHLORIDE OF 8-METHOXY-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE HAVING ACTIVITY AGAINST HYPOXIA AND PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Katkov V.F.
- Urjupov O.Ju.
|
SU1231835A1 |
| 2-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO(6,5-b)INDOL HYDROCHLORIDE POSSESSING ANTIHYPOXIC AND ANTIINFLAMMATORY ACTIVITY |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Poskalenko A.N.
- Ponomareva M.M.
|
SU1014250A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| ETHYL ESTER OF 1,2,4-TRIAZINO-(5,6-B)INDOLYL-3-THIOGLYCOLIC ACID IMPROVING PHYSICAL RESISTANCE AND RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Khromenkova Z.A.
- Vinogradov V.M.
- Spivakova R.P.
- Sumina Eh.N.
- Basieva T.S.
|
SU1233460A1 |
| 8-METHOXY-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]- INDOLE MALATE SHOWING ANTIHYPOXIC ACTIVITY |
1988 |
- Tomchin A.B.
- Marysheva V.V.
- Katkov V.F.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1547280A1 |
| 3-BENZOYLPHENYLMETHYLTHIO-1,2,4-TRIAZINO(5,6-B)INDOLE INCREASING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1981 |
- Tomchin A.B.
- Basieva T.S.
- Vinogradov V.M.
- Pastushenkov L.V.
- Urjupov O.Ju.
|
SU940476A1 |
| 3-(PIPERIDINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE SHOWING ANTIHYPOXIC ACTIVITY AND PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
- Urjupov O.Ju.
- Kostycheva M.V.
- Kropotov A.V.
- Butakov V.N.
|
SU1681504A1 |
