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Application

4635882/04, 1989-01-12

(22)

Actual filing date

1989-01-12

(45)

Published

1996-09-10

(72)

Inventor

Turzhova E.B.Zhukova T.I.Kuznetsova T.A.Tomchin A.B.

3-(MORPHOLINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE ENHANCING RESISTANCE TO HYPERCAPNIC HYPOXIA Russian patent published in 1996 - IPC

Abstract SU 1596719 A1

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(morpholinocarbonylmethylthio)-1,2,4-triazino-[5,6-b]-indole. Synthesis is carried out by interaction of 3-mercapto-1,2,4-triazino-[5,6-b]-indole with morpholinocarbonylmethyl chloride in the presence of NaOH in an aqueous medium. Yield is 91%, m. p. is 247 C (with charring), empirical formula is C15H15ON5S. New compound at toxicity LD50> above 20 g/kg (intragastral administration) at a single preliminary administration immediately before or 30 min before action at dose 25-30 mg/kg provides 100% survival as compared with LD50 = 12.5 g/kg, 60-70%-th survival for the known compound under the same conditions. Synthesized compound can be used in medicine. EFFECT: new compounds showing enhanced activity and less toxicity. 4 tbl

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SU 1 596 719 A1

Authors

Turzhova E.B.

Zhukova T.I.

Kuznetsova T.A.

Tomchin A.B.

Dates

1996-09-10—Published

1989-01-12—Filed

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