Patenton — panteon of patents

(19)

SU

(11)

1 769 528

(13)

A1

(51)

IPC

(21) (22)

Application

4885752/04, 1990-10-16

(22)

Actual filing date

1990-10-16

(45)

Published

1994-06-15

(72)

Inventor

Vizel' A.O.Arbuzov B.A.Ivanovskaja K.M.Shchukina L.I.Sharipova S.M.Zaikonnikova N.V.Studentsova I.A.Khafiz'Janova R.Kh.Mokrinskaja I.S.Garaev R.S.Zaljaljutdinova L.N.Novozhilova N.N.

DERIVATIVES OF 2-OXO-3,3,5-TRIMETHYL-1,2-OXAPHOSPHOLENE-4 SHOWING ANTIBLASTOMA ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1769528 A1

FIELD: organic chemistry. SUBSTANCE: product: 2-oxo-2-[2,3-epoxy-(propyl)oxy] -3,3,5-trimethyl-1,2-oxaphospholene-4 of the general formula , gross-formula is C19H15O4P, yield is 38.4%, b.p. is 115-117 C (at 0.04 mm mercury column); 2-oxo-2-(N-morpholino)-3,3,5-trimethyl-1,2-oxaphospholene-4 of the general formula , gross-formula C10H18NO3P, yield is 81.2%, b. p. is 124-126 C (at 0.02 mm mercury column). Reagent 1: . Reagent 2: HR, where R is . Reaction conditions: in the presence of acceptor of hydrogen chloride-triethylamine in the medium of organic solvent. EFFECT: synthesized compounds are used in medicine as antiblastoma drugs. 4 ex, 4 tbl

Similar patents SU1769528A1

Title Year Author Number
PROCESS FOR PREPARING SUBSTITUTED 1,3-OXAPHOSPHOLENES 0
  • Rodionov Igor Leonidovich
  • Kazankova Marina Aleksandrovna
  • Luzikov Yurij Nikolaevich
  • Lutsenko Ivan Fomich
 SU1114681A1
DERIVATIVE OF THE CLASS OF N-GLYCOSIDES INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE - N-{12-(β-D-XYLOPYRANOSYL)-5,7-DIOXO-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOL-6-YL} PYRIDINE-2-CARBOXAMIDE, WHICH HAS CYTOTOXIC AND ANTITUMOR ACTIVITY 2017
  • Golubeva Irina Sergeevna
  • Eremina Vera Aleksandrovna
  • Moiseeva Natalya Ivanovna
  • Ektova Lidiya Vladimirovna
  • Yavorskaya Nadezhda Petrovna
 RU2667906C1
METHOD OF OBTAINING 4-METHYL-2-OXO-2-CHLOR-1,2-OXAPHOSPHOLENE-3 2007
  • Mitrasov Jurij Nikitich
  • Smolina Irina Nikolaevna
  • Koljamshin Oleg Aktar'Evich
 RU2340620C1
COMPOSITION CONTAINING AMINO ACIDS AND TRACE ELEMENTS AND SHOWING ANTITUMOR AND ANTIHYPOXIC ACTIVITY 1994
  • Shtyrlin V.G.
  • Khafiz'Janova R.Kh.
  • Zaljaljutdinova L.N.
  • Mokrinskaja I.S.
  • Zakharov A.V.
  • Nazmutdinova G.A.
  • Garaev R.S.
 RU2125874C1
4(5)-(3-NITRO-4-(3,3-DIMETHYLTRIAZENO-1)PHENYL)IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY 1982
  • Iradjan M.A.
  • Iradjan N.S.
  • Stepanjan G.M.
  • Arsenjan F.G.
  • Garibdzhanjan B.T.
 SU1074091A1
BENZOTHIAZOLE DERIVATIVE OR ITS PHARMACOLOGICALLY ACCEPTABLE SALT 1992
  • Jasusi Okamoto[Jp]
  • Katsuja Tagami[Jp]
  • Sigeki Khibi[Jp]
  • Khirotosi Numata[Jp]
  • Naoki Kobajasi[Jp]
  • Masanobu Sinoda[Jp]
  • Tetsuja Kavakhara[Jp]
  • Manabu Murakami[Jp]
  • Kiesi Oketani[Jp]
  • Takasi Inoue[Jp]
  • Takasi Jamanaka[Jp]
  • Isao Jamatsu[Jp]
 RU2041216C1
N-PHOSPHORYLATED DERIVATIVES OF 3-β- PHENYLISOPROPYLSYDNONEIMINE SHOWING ANTITUMOR ACTIVITY 1991
  • Sokolova A.S.
  • Borisov E.V.
  • Vasil'Ev A.V.
  • Parshin V.A.
  • Zabrodin V.B.
  • Safonova T.S.
 RU2036914C1
5-BENZIL-11,13-DIMETHHYL-2,8,12-TRIOXO-1,5,9-TRIAZACYCLO [9,3,1,1] HEXADECANE, POSSESSING ANTITUMOR ACTIVITY 1985
  • Agadzhanjan Ts.E.
  • Arutjunjan G.L.
  • Garibdzhanjan B.T.
  • Chachojan A.A.
 SU1285754A1
0
SU218176A1
2-BIS-(β- CHLOROETHYL)- AMINO- OR 2-PHENOXY -5,7-DIMETHYL -2,6-DIOXO- 1,3-DIAZA -2-PHOSPHAADAMANTANES SHOWING ANTITUMOR ACTIVITY 1985
  • Agadzhanjan Ts.E.
  • Arutjunjan G.L.
  • Chachojan A.A.
  • Muradjan R.E.
 SU1282521A1

SU 1 769 528 A1

Authors

Vizel' A.O.

Arbuzov B.A.

Ivanovskaja K.M.

Shchukina L.I.

Sharipova S.M.

Zaikonnikova N.V.

Studentsova I.A.

Khafiz'Janova R.Kh.

Mokrinskaja I.S.

Garaev R.S.

Zaljaljutdinova L.N.

Novozhilova N.N.

Dates

1994-06-15—Published

1990-10-16—Filed

read Similar patents